育龄期埃塞俄比亚妇女叶酸缺乏：系统评价和荟萃分析。

Folate deficiency among women of reproductive age in Ethiopia: A systematic review and meta-analysis.

机构信息

School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.

School of Health and Medical Sciences, University of Southern Queensland, Queensland, Australia.

出版信息

PLoS One. 2023 May 8;18(5):e0285281. doi: 10.1371/journal.pone.0285281. eCollection 2023.

DOI:10.1371/journal.pone.0285281

PMID:37155667

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10166565/

Abstract

BACKGROUND

Folate deficiency (FD) can cause adverse health outcomes of public health significance. Although FD is a significant micronutrient deficiency in Ethiopia, concrete evidence is limited. Therefore, this systematic review and meta-analysis was designed to estimate the pooled prevalence of FD among women of reproductive age (WRA).

METHODS

A systematic literature search was performed using MEDLINE, Embase, CINAHL, Google Scholar, African Journals Online (AJOL), The Vitamin and Mineral Nutrition Information System (VMNIS) of the World Health Organization (WHO), Global Health Data Exchange (GHDx), and institutional repositories of major universities and research centers. Additionally, we scanned the reference lists of relevant articles. Two authors independently selected the studies, extracted the data, and the study risk of bias. Heterogeneity was assessed using the I2 statistic. We used a random-effects model to estimate the pooled mean serum/plasma folate and the pooled prevalence of FD. Begg's and Egger's tests were used to check publication bias.

RESULTS

Ten studies-nine cross-sectional and one case-control-with a total of 5,623 WRA were included in the systematic review and meta-analysis. Four (WRA = 1,619) and eight (WRA = 5,196) cross-sectional studies were used to estimate the pooled mean serum/plasma folate and prevalence of FD, respectively. The pooled mean serum/plasma folate concentration estimate was 7.14 ng/ml (95% CI: 5.73, 8.54), and the pooled prevalence of FD was estimated to be 20.80% (95% CI: 11.29, 32.27). In addition the meta-regression analysis showed that the sampling technique was significantly associated with mean serum/plasma folate concentration.

CONCLUSIONS

FD is a significant public health issue among WRA in Ethiopia. Therefore, the public health strategies of the country should focus on promoting the consumption of folate-rich foods, strengthening the coverage of folic acid supplementation and its adherence, and swift translation of the mandatory folic acid fortification into action.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO 2022-CRD42022306266.

摘要

背景

叶酸缺乏（FD）可导致具有公共卫生重要意义的不良健康后果。尽管 FD 是埃塞俄比亚一个重要的微量营养素缺乏症，但具体证据有限。因此，本系统评价和荟萃分析旨在估计育龄妇女（WRA）中 FD 的总患病率。

方法

使用 MEDLINE、Embase、CINAHL、Google Scholar、非洲在线期刊（AJOL）、世界卫生组织（WHO）的维生素和矿物质营养信息系统（VMNIS）、全球卫生数据交换（GHDx）以及主要大学和研究中心的机构存储库进行系统文献检索。此外，我们还扫描了相关文章的参考文献列表。两位作者独立选择研究、提取数据和研究偏倚风险。使用 I2 统计量评估异质性。我们使用随机效应模型估计血清/血浆叶酸的总平均值和 FD 的总患病率。使用 Begg 和 Egger 检验检查发表偏倚。

结果

共纳入 10 项研究（9 项横断面研究和 1 项病例对照研究），其中共有 5623 名 WRA。四项（WRA=1619）和八项（WRA=5196）横断面研究用于估计血清/血浆叶酸的总平均值和 FD 的总患病率。血清/血浆叶酸浓度的总平均值估计为 7.14ng/ml（95%CI：5.73，8.54），FD 的总患病率估计为 20.80%（95%CI：11.29，32.27）。此外，元回归分析表明，抽样技术与血清/血浆叶酸浓度有显著相关性。