From the Department of Surgery, University of Toledo, College of Medicine and Life Science.
Ann Plast Surg. 2023 Oct 1;91(4):433-440. doi: 10.1097/SAP.0000000000003558. Epub 2023 May 9.
Cultured epithelial autografts (CEAs) have been used for decades as a treatment for massive burn injuries. Cultured epithelial autografts allow for wounds to heal by taking a small sample and growing a patient's own epithelium in culture to create large, graftable sheets. This technique is especially useful in large wounds where donor sites are limited compared with conventional skin grafting. However, CEAs have a variety of uses in wound healing and reconstruction and have the potential to aid in the closure of several types of defects. Cultured epithelial autografts have shown applicability in large burns, chronic nonhealing wounds, ulcerating wounds of various etiologies, congenital defects, wounds requiring specialized epithelium to replace like by like, and wounds in critically ill patients. Several factors must be considered when using CEAs, such as time, cost, and outcomes. In this article, we detail the various clinical applications of CEAs and how they can be situationally advantageous outside of their original purpose.
培养的自体上皮移植物（CEAs）已被用于治疗大面积烧伤数十年。培养的自体上皮移植物通过从小样本中获取并在培养中生长患者自身的上皮来允许伤口愈合，从而形成大片可移植的薄片。与传统的皮肤移植相比，这种技术在供体部位有限的大伤口中特别有用。但是，CEAs 在伤口愈合和重建中有多种用途，并且有可能帮助闭合几种类型的缺陷。培养的自体上皮移植物已在大面积烧伤、慢性不愈合伤口、各种病因的溃疡性伤口、先天性缺陷、需要特殊上皮替代的伤口以及重症患者的伤口中显示出适用性。使用 CEAs 时必须考虑多个因素，例如时间、成本和结果。在本文中，我们详细介绍了 CEAs 的各种临床应用，以及它们在原始用途之外的情况下如何具有优势。
