Zhang Qiu, Mao WeiLin, He Xia, Yuan ManChun
Department of Clinical Laboratory, Shengzhou People's Hospital, Shengzhou Branch of the First Affiliated Hospital of Zhejiang University, Shengzhou, 312400, China.
Department of Clinical Laboratory, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
Biomark Med. 2023 Feb;17(4):189-196. doi: 10.2217/bmm-2023-0123. Epub 2023 May 9.
This work was designed to determine the association between red cell distribution width-to-platelet ratio (RPR) and 30-day prognosis in hepatitis B virus-associated decompensated cirrhosis (HBV-DC) patients. A total of 168 HBV-DC patients were included. Independent risk factors for poor prognosis were determined by logistic regression analyses. A total of 21 (12.5%) patients died within 30 days. RPR was higher in nonsurvivors than in survivors. Multivariate analysis identified RPR and Model for End-Stage Liver Disease (MELD) score as independent prognostic predictors, and the predictive value of RPR was similar to that of the MELD score. Moreover, combining RPR with the MELD score further improved the predictive value for mortality. RPR has potential as a reliable tool for the prediction of poor prognosis in HBV-DC patients.
这项研究旨在确定红细胞分布宽度与血小板比值（RPR）和乙型肝炎病毒相关性失代偿期肝硬化（HBV-DC）患者30天预后之间的关联。共纳入168例HBV-DC患者。通过逻辑回归分析确定预后不良的独立危险因素。共有21例（12.5%）患者在30天内死亡。非幸存者的RPR高于幸存者。多变量分析确定RPR和终末期肝病模型（MELD）评分是独立的预后预测指标，且RPR的预测价值与MELD评分相似。此外，将RPR与MELD评分相结合可进一步提高对死亡率的预测价值。RPR有潜力成为预测HBV-DC患者预后不良的可靠工具。
