Mao WeiLin, Yuan ManChun, He Xia, Zhang Qiu
Department of Clinical Laboratory, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Department of Clinical Laboratory, Shengzhou People's Hospital, Shengzhou Branch of the First Affiliated Hospital of Zhejiang University, Shengzhou, China.
Lab Med. 2024 Mar 7;55(2):127-131. doi: 10.1093/labmed/lmad048.
The aim of this study was to ascertain whether red cell distribution width-to-albumin ratio (RAR) is associated with survival in hepatitis B virus (HBV)-associated decompensated cirrhosis (DC) patients.
A cohort of 167 patients with confirmed HBV-DC was enrolled in our study. Demographic characteristics and laboratory data were obtained. The main endpoint was mortality at 30 days. The receiver operating characteristic curve and multivariable regression analysis were used to assess the power of RAR for predicting prognosis.
Mortality at 30 days was 11.4% (19/167). The RAR levels were higher in the nonsurvivors than the survivors, and elevated RAR levels were clearly associated with poor prognosis. Moreover, the predictive powers of RAR and Model for End-Stage Liver Disease score were not obviously different.
Our data indicate that RAR is a novel potential prognostic biomarker of mortality in HBV-DC.
本研究旨在确定红细胞分布宽度与白蛋白比值（RAR）是否与乙型肝炎病毒（HBV）相关失代偿期肝硬化（DC）患者的生存率相关。
本研究纳入了167例确诊为HBV-DC的患者。获取了人口统计学特征和实验室数据。主要终点是30天死亡率。采用受试者工作特征曲线和多变量回归分析来评估RAR预测预后的能力。
30天死亡率为11.4%（19/167）。非幸存者的RAR水平高于幸存者，且RAR水平升高与预后不良明显相关。此外，RAR和终末期肝病模型评分的预测能力没有明显差异。
我们的数据表明，RAR是HBV-DC患者死亡率的一种新型潜在预后生物标志物。
