School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Eur J Neurol. 2023 Aug;30(8):2250-2260. doi: 10.1111/ene.15839. Epub 2023 May 21.
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Mindfulness and meditation therapies have been demonstrated as effective alternative treatments for patients with neurological disorders. However, the effects of mindfulness and meditation therapies on PD remain unclear. This meta-analysis investigated the effects of mindfulness and meditation therapies in PD patients.
A literature search was conducted using PubMed, Embase, Cochrane Library, and ClinicalTrials.gov for randomized controlled trials comparing mindfulness and meditation therapies with control treatments in patients with PD.
Nine articles involving eight trials were included, with a total of 337 patients. Our meta-analysis revealed that mindfulness and meditation therapies significantly improved Unified Parkinson's Disease Rating Scale-Part III score (mean difference [MD] = -6.31, 95% confidence interval [95% CI] = -8.57 to -4.05) and cognitive function (standard mean difference [SMD] = 0.62, 95% CI = 0.23 to 1.02). However, no significant differences were discovered between mindfulness therapies and control in gait velocity (MD = 0.05, 95% CI = -0.23 to 0.34), Parkinson's Disease Questionnaire-39 Summary Index (MD = 0.51, 95% CI = -1.12 to 2.14), activities of daily living (SMD = -1.65, 95% CI = -3.74 to 0.45), depression (SMD = -0.43, 95% CI = -0.97 to 0.11), anxiety (SMD = -0.80, 95% CI = -1.78 to 0.19), pain (SMD = 0.79, 95% CI = -1.06 to 2.63), or sleep disturbance (SMD = -0.67, 95% CI = -1.58 to 0.24).
Mindfulness and meditation therapies may serve as complementary and alternative treatments for PD patients.
帕金森病（PD）是全球第二常见的神经退行性疾病。正念和冥想疗法已被证明是治疗神经障碍患者的有效替代疗法。然而，正念和冥想疗法对 PD 的影响尚不清楚。本荟萃分析旨在研究正念和冥想疗法对 PD 患者的影响。
使用 PubMed、Embase、Cochrane 图书馆和 ClinicalTrials.gov 对比较正念和冥想疗法与 PD 患者对照治疗的随机对照试验进行文献检索。
纳入了 9 篇文章，涉及 8 项试验，共 337 名患者。我们的荟萃分析显示，正念和冥想疗法可显著改善统一帕金森病评定量表第三部分评分（平均差异 [MD] = -6.31，95%置信区间 [95%CI] = -8.57 至 -4.05）和认知功能（标准化均数差 [SMD] = 0.62，95%CI = 0.23 至 1.02）。然而，正念疗法与对照组在步态速度（MD = 0.05，95%CI = -0.23 至 0.34）、帕金森病问卷-39 总结指数（MD = 0.51，95%CI = -1.12 至 2.14）、日常生活活动（SMD = -1.65，95%CI = -3.74 至 0.45）、抑郁（SMD = -0.43，95%CI = -0.97 至 0.11）、焦虑（SMD = -0.80，95%CI = -1.78 至 0.19）、疼痛（SMD = 0.79，95%CI = -1.06 至 2.63）或睡眠障碍（SMD = -0.67，95%CI = -1.58 至 0.24）方面无显著差异。
正念和冥想疗法可能是 PD 患者的补充和替代治疗方法。
