Susick R L, Abrams G D, Zurawski C A, Zannoni V G
Toxicol Appl Pharmacol. 1986 Jun 30;84(2):329-35. doi: 10.1016/0041-008x(86)90141-9.
Protection against the toxic effects of chronic alcohol consumption was observed in male guinea pigs maintained on a high-ascorbic-acid diet (vitamin C-deficient chow plus 2.0 mg ascorbic acid/ml drinking water) as compared to animals on a low-ascorbic-acid diet (vitamin C-deficient chow and from 0.025 to 0.050 mg ascorbic acid/ml drinking water). Alcohol was orally administered to the guinea pigs at a dose of 2.5 g/kg for up to 14 weeks. Levels of serum aspartate aminotransferase and serum alanine aminotransferase were significantly elevated in animals on the low-ascorbic-acid diet that received alcohol, 120 and 250%, respectively. In contrast, in animals on the high-ascorbic-acid diet that received alcohol, levels of alanine aminotransferase were not significantly elevated and levels of aspartate aminotransferase were elevated 50%. In addition, some of the animals on the low-ascorbic-acid diet that received alcohol for 12 to 14 weeks developed hepatic steatosis and necrosis, whereas none of the animals on the high-ascorbic-acid diet that received alcohol for the same length of time manifested these changes.
与低抗坏血酸饮食（缺乏维生素C的食物加0.025至0.050毫克抗坏血酸/毫升饮用水）的雄性豚鼠相比，在高抗坏血酸饮食（缺乏维生素C的食物加2.0毫克抗坏血酸/毫升饮用水）的雄性豚鼠中观察到对长期饮酒毒性作用的保护作用。以2.5克/千克的剂量给豚鼠口服酒精，持续14周。接受酒精的低抗坏血酸饮食动物的血清天冬氨酸转氨酶和血清丙氨酸转氨酶水平分别显著升高120%和250%。相比之下，接受酒精的高抗坏血酸饮食动物的丙氨酸转氨酶水平没有显著升高，天冬氨酸转氨酶水平升高了50%。此外，一些接受酒精12至14周的低抗坏血酸饮食动物出现了肝脂肪变性和坏死，而接受相同时间酒精的高抗坏血酸饮食动物均未出现这些变化。
