F-344大鼠中2-己酮与四氯化碳之间的肝肾相互作用。

Renal and hepatic interactions between 2-hexanone and carbon tetrachloride in F-344 rats.

作者信息

Raisbeck M F, Brown E M, Hewitt W R

出版信息

Toxicol Lett. 1986 Apr;31(1):15-21. doi: 10.1016/0378-4274(86)90189-x.

Abstract

Fisher-344 rats were pretreated with 2-hexanone (HX) and challenged with carbon tetrachloride (CCl4) in a replicated 3 X 4 factorial experiment to determine if HX potentiated CCL4-induced renal and hepatic damage. Rats given both HX and CCl4 demonstrated more severe hepatic injury at 24 and 48 h than did controls. However, in contrast to our experience with chloroform (CHCl3), CCl4-induced renal injury in HX-pretreated rats was only slightly greater than in vehicle-pretreated controls.

摘要

在一项重复的3×4析因实验中，对费希尔344大鼠先用2 -己酮（HX）进行预处理，然后用四氯化碳（CCl4）进行激发，以确定HX是否会增强CCl4诱导的肾和肝损伤。同时给予HX和CCl4的大鼠在24小时和48小时时表现出比对照组更严重的肝损伤。然而，与我们使用氯仿（CHCl3）的经验不同，HX预处理大鼠中CCl4诱导的肾损伤仅比赋形剂预处理的对照组略大。