Saliba Luke, Sammut Keith, Tonna Christabelle, Pavli Foteini, Valdramidis Vasilis, Gatt Ray, Giordmaina Ryan, Camilleri Liberato, Atanasio William, Buhagiar Joseph, Schembri Wismayer Pierre
Department of Trauma, Orthopaedics and Sports Medicine, Mater Dei Hospital, Msida, MSD 2090, Malta.
Department of Anatomy, University of Malta, Msida, MSD 2080, Malta.
Heliyon. 2023 Apr 21;9(5):e15671. doi: 10.1016/j.heliyon.2023.e15671. eCollection 2023 May.
Iron-based biodegradable metal bone graft substitutes are in their infancy but promise to fill bone defects that arise after incidents such as trauma and revision arthroplasty surgery. Before clinical use however, a better understanding of their biodegradability, potential cytotoxicity and biocompatibility is required. In addition, these implants must ideally be able to resist infection, a complication of any implant surgery. In this study there was significant cytotoxicity caused by pure Fe, FeMn, FeMn1Ag and FeMn5Ag on both human foetal osteoblast (hFOB) and mouse pre-osteoblast (MC3T3-E1) cell lines. experiments on the other hand showed no signs of ill-effect on GAERS rats with the implanted FeMn, FeMn1Ag and FeMn5Ag pins being removed largely uncorroded. All Fe-alloys showed anti-bacterial performance but most markedly so in the Ag-containing alloys, there is significant bacterial resistance .
铁基可生物降解金属骨移植替代物尚处于起步阶段，但有望填补创伤和翻修关节置换手术等事故后出现的骨缺损。然而，在临床使用之前，需要更好地了解它们的生物降解性、潜在细胞毒性和生物相容性。此外，这些植入物理想情况下必须能够抵抗感染，这是任何植入手术的一种并发症。在本研究中，纯铁、铁锰、铁锰1银和铁锰5银对人胎儿成骨细胞（hFOB）和小鼠前成骨细胞（MC3T3-E1）细胞系均有显著的细胞毒性。另一方面，实验表明，植入的铁锰、铁锰1银和铁锰5银销钉在很大程度上未被腐蚀地取出，对GAERS大鼠没有不良影响的迹象。所有铁合金都表现出抗菌性能，但含银合金最为明显，具有显著的抗菌性。
