Cherqaoui Abdelhakim, Cao Quang Nguyen, Gatto Maria Laura, Paternoster Carlo, Mengucci Paolo, Mantovani Diego
Laboratory for Biomaterials and Bioengineering, Canada Research Chair I in Biomaterials and Bioengineering for the Innovation in Surgery, Department of Min-Met-Materials Engineering, Research Center of CHU de Quebec, Division of Regenerative Medicine, Laval University, Quebec City, Canada.
Department DIISM, Università Politecnica Delle Marche, Via Brecce Bianche 12, 60131, Ancona, Italy.
Bioact Mater. 2024 Jul 16;41:96-107. doi: 10.1016/j.bioactmat.2024.06.025. eCollection 2024 Nov.
This study investigates the degradation behavior of three distinct Fe-based alloys immersed in three pseudo-physiological solutions. These alloys, which have varied Mn and C contents, include a commercially available Fe-0.15C alloy, namely Fe-C, and two newly developed alloys, that is Fe-5Mn-0.2C (namely Fe-5Mn) and Fe-18Mn-0.6C (namely Fe-18Mn). The aim was to understand the effect of alloying elements and the testing solution on the degradation behavior of these Fe-based materials. Static immersion degradation and potentiodynamic corrosion tests were carried out using three pseudo-physiological solutions with albumin supply, that is modified Hanks' saline solution (MHSS), phosphate buffered saline solution (PBS), and sodium chloride solution (NaCl). After two weeks of static immersion, the results revealed that Fe-5Mn, characterized by a mixture of ferrite and martensite, showed the highest degradation rate, while Fe-C, composed solely of ferrite, showed the lowest rate of degradation. The predominant degradation products in MHSS and PBS were phosphates and carbonates. In PBS, these products formed a remarkably stable protective layer on the surface, contributing to the lowest degradation rate. In contrast, porous hydroxides appeared as the main degradation products for samples immersed in NaCl solution, leading to the highest degradation rate. These results provided important insights into the customization of Fe-Mn-C alloys for a range of biomedical applications, meeting a variety of clinical requirements, and highlighting the considerable potential of Fe-Mn-C alloys for biomedical applications.
本研究调查了三种不同的铁基合金浸泡在三种模拟生理溶液中的降解行为。这些合金的锰和碳含量各不相同，包括一种市售的Fe-0.15C合金，即Fe-C，以及两种新开发的合金，即Fe-5Mn-0.2C（即Fe-5Mn）和Fe-18Mn-0.6C（即Fe-18Mn）。目的是了解合金元素和测试溶液对这些铁基材料降解行为的影响。使用三种含白蛋白供应的模拟生理溶液进行静态浸泡降解和动电位腐蚀试验，即改良汉克斯盐溶液（MHSS）、磷酸盐缓冲盐水溶液（PBS）和氯化钠溶液（NaCl）。静态浸泡两周后，结果表明，以铁素体和马氏体混合物为特征的Fe-5Mn降解速率最高，而仅由铁素体组成的Fe-C降解速率最低。MHSS和PBS中的主要降解产物是磷酸盐和碳酸盐。在PBS中，这些产物在表面形成了一层非常稳定的保护层，导致降解速率最低。相比之下，多孔氢氧化物是浸泡在NaCl溶液中的样品的主要降解产物，导致降解速率最高。这些结果为定制用于一系列生物医学应用的Fe-Mn-C合金提供了重要见解，满足了各种临床需求，并突出了Fe-Mn-C合金在生物医学应用中的巨大潜力。
