International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou, 225009, China.
Laboratory of Plant Functional Genomics of the Ministry of Education, Yangzhou University, Yangzhou, 225009, China.
Plant Cell Rep. 2023 Aug;42(8):1255-1264. doi: 10.1007/s00299-023-03024-7. Epub 2023 May 9.
Iron-sulfur (Fe-S) clusters are ancient protein cofactors ubiquitously exist in organisms. They are involved in many important life processes. Plastids are semi-autonomous organelles with a double membrane and it is believed to originate from a cyanobacterial endosymbiont. By learning form the research in cyanobacteria, a Fe-S cluster biosynthesis and delivery pathway has been proposed and partly demonstrated in plastids, including iron uptake, sulfur mobilization, Fe-S cluster assembly and delivery. Fe-S clusters are essential for the downstream Fe-S proteins to perform their normal biological functions. Because of the importance of Fe-S proteins in plastid, researchers have made a lot of research progress on this pathway in recent years. This review summarizes the detail research progress made in recent years. In addition, the scientific problems remained in this pathway are also discussed.
铁硫（Fe-S）簇是古老的蛋白质辅因子，普遍存在于生物体内。它们参与许多重要的生命过程。质体是具有双层膜的半自主细胞器，据信它起源于蓝细菌的内共生体。通过借鉴蓝细菌的研究，人们提出了一种 Fe-S 簇生物合成和递呈途径，并在质体中部分得到了证实，包括铁的摄取、硫的动员、Fe-S 簇的组装和递呈。Fe-S 簇对于下游 Fe-S 蛋白发挥正常的生物学功能至关重要。由于 Fe-S 蛋白在质体中的重要性，近年来研究人员在该途径上取得了大量研究进展。本综述总结了近年来取得的详细研究进展。此外，还讨论了该途径中存在的科学问题。
