中孕期人类肠神经系统的解剖和功能成熟。
Anatomical and functional maturation of the mid-gestation human enteric nervous system.
机构信息
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, 94305, USA.
出版信息
Nat Commun. 2023 May 9;14(1):2680. doi: 10.1038/s41467-023-38293-z.
Immature gastrointestinal motility impedes preterm infant survival. The enteric nervous system controls gastrointestinal motility, yet it is unknown when the human enteric nervous system matures enough to carry out vital functions. Here we demonstrate that the second trimester human fetal enteric nervous system takes on a striped organization akin to the embryonic mouse. Further, we perform ex vivo functional assays of human fetal tissue and find that human fetal gastrointestinal motility matures in a similar progression to embryonic mouse gastrointestinal motility. Together, this provides critical knowledge, which facilitates comparisons with common animal models to advance translational disease investigations and testing of pharmacological agents to enhance gastrointestinal motility in prematurity.
不成熟的胃肠道动力会阻碍早产儿的生存。肠神经系统控制胃肠道动力，但目前尚不清楚人类肠神经系统何时成熟到足以发挥重要功能。在这里，我们证明了人类胎儿肠神经系统在第二个三个月呈现出类似于胚胎小鼠的条纹组织。此外，我们对人类胎儿组织进行了离体功能检测，发现人类胎儿胃肠道动力的成熟过程与胚胎小鼠胃肠道动力的成熟过程相似。总的来说，这提供了重要的知识，有助于与常见的动物模型进行比较，以推进转化疾病研究和测试药物来增强早产儿的胃肠道动力。
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