Department of Pathology and USC/Norris Comprehensive Cancer Center, Keck School of Medicine of University of Southern California, Los Angeles, California 90033, USA.
Department of Pathology and USC/Norris Comprehensive Cancer Center, Keck School of Medicine of University of Southern California, Los Angeles, California 90033, USA
Cold Spring Harb Perspect Med. 2023 Jul 5;13(7):a040642. doi: 10.1101/cshperspect.a040642.
The embryology of the female reproductive organs is reviewed focusing on aspects relevant to the histogenesis of reproductive neoplasms. The evidence reviewed suggests that (1) there is no embryological link between the ovarian surface epithelium and the coelomic epithelium; (2) the ovarian surface epithelium is not composed of pluripotent cells that readily differentiate into various components of the reproductive tract before or after birth; (3) there is no embryological link between the ovarian surface epithelium and the Müllerian ducts, from which internal female reproductive organs other than the ovaries, including the endocervix, endometrium, and fallopian tubes, are derived; and (4) there is an embryological link between the Müllerian ducts and the renal collecting system, perhaps accounting for clear cell differentiation in some gynecological malignancies. Implications for our understanding of the origin of the tumors historically classified as ovarian epithelial neoplasms are discussed.
本文重点回顾了女性生殖器官的胚胎学，以探讨与生殖系统肿瘤发生相关的方面。综述证据表明：（1）卵巢表面上皮与体腔上皮之间没有胚胎学联系；（2）卵巢表面上皮并非由多能细胞组成，在出生前或出生后，这些细胞不易分化为生殖管道的各种成分；（3）卵巢表面上皮与苗勒管之间没有胚胎学联系，苗勒管是除卵巢以外的内部女性生殖器官（包括宫颈内膜、子宫内膜和输卵管）的来源；（4）苗勒管与肾集合系统之间存在胚胎学联系，这可能解释了某些妇科恶性肿瘤中透明细胞分化的现象。讨论了这些发现对我们理解历史上归类为卵巢上皮性肿瘤的肿瘤起源的意义。
