Lionetti Elena, Dominijanni Vera, Iasevoli Mario, Cimadamore Elisa, Acquaviva Ilaria, Gatti Simona, Monachesi Chiara, Catassi Giulia, Pino Alessandra, Faragalli Andrea, Randazzo Cinzia Lucia, Gesuita Rosaria, Malamisura Basilio, Catassi Carlo
Division of Pediatrics and Center for Celiac Research, DISCO Department, Marche Polytechnic University, Ancona, Italy.
Pediatric Unit and Center for Celiac Disease - University Hospital of Salerno, Campus of Cava de' Tirreni, Italy.
Dig Liver Dis. 2023 Oct;55(10):1328-1337. doi: 10.1016/j.dld.2023.04.021. Epub 2023 May 9.
To evaluate the efficacy of a multispecies probiotic on clinical and laboratory recovery of children with celiac disease (CeD) at diagnosis.
Children with newly diagnosed CeD entered a randomized double-blind placebo-controlled trial. A gluten-free diet (GFD) plus a multispecies probiotic or placebo were administered for 12 weeks. Growth, laboratory, and clinical parameters were recorded at enrollment, after 3 and 6 months of follow-up.
Overall, 96 children completed the study: 49 in group A (placebo) and 47 in group B (probiotic). A significant increase of BMI-Z score was found in both groups after 3 and 6 months of treatment (p < 0.001), however the increase of BMI-Z score was significantly higher and faster in Group B than in Group A. Other clinical and laboratory parameters improved in both groups after 3 and 6 months (p<0.001), but no difference was found between the groups and a comparable time trend was observed in both groups.
Treatment with a multispecies probiotic induced a higher and faster increase of BMI in children with newly diagnosed CeD. The mechanism of this positive effect remains to be elucidated.
评估一种多菌种益生菌对乳糜泻（CeD）患儿诊断时临床及实验室指标恢复情况的疗效。
新诊断为CeD的患儿进入一项随机双盲安慰剂对照试验。给予无麸质饮食（GFD）加一种多菌种益生菌或安慰剂，持续12周。在入组时、随访3个月和6个月后记录生长、实验室及临床参数。
总体上，96名儿童完成了研究：A组（安慰剂组）49名，B组（益生菌组）47名。治疗3个月和6个月后，两组的BMI-Z评分均显著增加（p<0.001），然而B组BMI-Z评分的增加显著高于且快于A组。3个月和6个月后，两组的其他临床和实验室参数均有所改善（p<0.001），但两组之间未发现差异，且两组观察到类似的时间趋势。
新诊断为CeD的患儿使用多菌种益生菌治疗可使BMI升高更高且更快。这种积极作用的机制仍有待阐明。
