Gupta Nishant, Al-Dossari M, El-Gawaad N S Abd, Alghamdi Saad, Qusty Naeem F, Babalghith Ahmad O, Yadav Virendra Kumar, Niazi Parwiz, Mallasiy L O
Medical Division, River Engineering Private Limited, Ecotech-3, Greater Noida, India.
Muhayil Asir, Applied College, King Khalid University, 62529, Abha, Saudi Arabia.
Probiotics Antimicrob Proteins. 2025 Mar 19. doi: 10.1007/s12602-025-10514-5.
The only approved preventive treatment option GFD remains insufficient to manage Celiac Disease (CeD). A cohort of probiotic bacteria recently indicated that probiotic bacteria such as L. plantarum (LP) have a protective effect on CeD. LP has been a prominent probiotic, studied for numerous modulating properties. This review highlights and summarizes LP's ameliorating effect on various triggers/drivers of CeD. Probiotic LP potential for CeD is noticeable, mainly involving gut microbiota modulation, gluten digestion, intestinal homeostasis, CeD-associated pathogens reduction, and CD4 + T cell regulation. LP supplementation maintains intestinal physiology by improving the ratio of intestinal villus height to crypt depth. Gut microbiota modulation also improves tight junction proteins and the intestinal barrier. LP increases the digestibility of immunoreactive 33-mer gliadin peptides and regulates immune triggers such as CD4 + T cells. LP supplementation may minimize the gastrointestinal symptoms of CeD. Nevertheless, the therapeutic applicability of LP is subjected to significant clinical and nonclinical studies.
唯一被批准的乳糜泻预防性治疗方案——无谷蛋白饮食（GFD）仍不足以控制乳糜泻（CeD）。最近一组益生菌表明，诸如植物乳杆菌（LP）等益生菌对CeD具有保护作用。LP一直是一种重要的益生菌，对其多种调节特性进行了研究。本综述重点介绍并总结了LP对CeD各种触发因素/驱动因素的改善作用。益生菌LP对CeD的潜在作用值得关注，主要涉及肠道微生物群调节、麸质消化、肠道内环境稳态、与CeD相关的病原体减少以及CD4 + T细胞调节。补充LP通过改善肠绒毛高度与隐窝深度的比例来维持肠道生理功能。肠道微生物群调节还可改善紧密连接蛋白和肠道屏障。LP可提高免疫反应性33聚体麦醇溶蛋白肽的消化率，并调节免疫触发因素，如CD4 + T细胞。补充LP可能会减轻CeD的胃肠道症状。然而，LP的治疗适用性还需要大量的临床和非临床研究。
