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深海水改变了北太平洋巨型鱿鱼的胆固醇和矿物质代谢，抑制了其体重减轻。

Deep ocean water alters the cholesterol and mineral metabolism of squid Todarodes pacificus and suppresses its weight loss.

机构信息

Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Ogi, Noto-cho, Ishikawa, 927-0553, Japan.

Marine Biological Science Section, Education and Research Center for Biological Resources, Faculty of Life and Environmental Science, Shimane University, Oki, Shimane, 685-0024, Japan.

出版信息

Sci Rep. 2023 May 10;13(1):7591. doi: 10.1038/s41598-023-34443-x.

DOI:10.1038/s41598-023-34443-x
PMID:37164992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10172372/
Abstract

This study is the first to demonstrate that deep ocean water (DOW) has physiological significant effects on squid. After 36 h of rearing squids, those reared with DOW had significantly higher total and free cholesterol levels and lower alanine transaminase activity in hemolymph as compared with those reared with surface sea water (SSW). SSW rearing also resulted in 6.95% weight loss, while DOW rearing caused only 2.5% weight loss, which might be due to liver metabolism suppression. Furthermore, both monovalent (sodium, chloride, and potassium ions) and divalent (calcium, inorganic phosphorus, and magnesium ions) ions in hemolymph were elevated when reared with DOW compared to those when reared with SSW. A study of genes expressed in the brain revealed that five genes were specifically remarked in DOW rearing. Most altered genes were neuropeptides, including those from vasopressin superfamily. These neuropeptides are involved in cholesterol and/or mineral metabolisms and physiological significant effects on squid. This study is the first report the effects of DOW on cholesterol and mineral metabolism of squid and will contribute to squid aquaculture using DOW.

摘要

本研究首次证明深海海水（DOW）对鱿鱼具有生理显著影响。在饲养鱿鱼 36 小时后，与用表层海水（SSW）饲养的鱿鱼相比，用 DOW 饲养的鱿鱼血液中的总胆固醇和游离胆固醇水平显著升高，丙氨酸氨基转移酶活性降低。SSW 饲养还导致 6.95%的体重减轻，而 DOW 饲养仅导致 2.5%的体重减轻，这可能是由于肝脏代谢受到抑制。此外，与用 SSW 饲养相比，用 DOW 饲养时血液中的单价（钠离子、氯离子和钾离子）和二价（钙离子、无机磷和镁离子）离子都升高了。对大脑中表达的基因的研究表明，有五个基因在 DOW 饲养中特别明显。大多数改变的基因是神经肽，包括来自加压素超家族的基因。这些神经肽参与胆固醇和/或矿物质代谢，并对鱿鱼具有生理显著影响。本研究首次报道了 DOW 对鱿鱼胆固醇和矿物质代谢的影响，将有助于使用 DOW 进行鱿鱼养殖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/db2d41d4d581/41598_2023_34443_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/6a916d15094c/41598_2023_34443_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/e435eee29887/41598_2023_34443_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/fa28059eb769/41598_2023_34443_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/341f36f23f88/41598_2023_34443_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/7c82dabb3887/41598_2023_34443_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/70cc4edfc392/41598_2023_34443_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/59d8bdee8285/41598_2023_34443_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/db2d41d4d581/41598_2023_34443_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/6a916d15094c/41598_2023_34443_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/e435eee29887/41598_2023_34443_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/fa28059eb769/41598_2023_34443_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/341f36f23f88/41598_2023_34443_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/7c82dabb3887/41598_2023_34443_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/70cc4edfc392/41598_2023_34443_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/59d8bdee8285/41598_2023_34443_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e26/10172372/db2d41d4d581/41598_2023_34443_Fig8_HTML.jpg

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