Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
Curr Vasc Pharmacol. 2023;21(3):185-196. doi: 10.2174/1570161121666230510141338.
Cardiometabolic diseases, such as type 2 diabetes mellitus (DM) and cardiovascular disease (CVD), are a great health concern. The strategies aimed to increase awareness and prevention, in conjunction with timely diagnosis and optimal management of these conditions, represent the main lines of action to improve life expectancy and quality. In recent years, the introduction of innovative therapies for the treatment of DM and CVD has provided new hope for high-risk patients. Yet, the implementation of preventive measures in achieving cardiometabolic health is far from successful and requires further improvement. The development of cardiometabolic disorders is a complex, multifactorial process involving several metabolic pathways as well as genetic and environmental factors. Decreasing cumulative exposure during the entire life course and timely recognition and targeting of potential riskenhancing factors could pave the way toward more successful prevention of cardiometabolic disorders. Nowadays, in the era of "omics" technologies, it is possible to identify novel biomarkers and therapeutic targets, which offers the possibility to apply an individualized approach for each patient. This review will discuss potential applications of genomic, transcriptomic, epigenetic and metabolomic biomarkers for the personalized prevention of cardiometabolic diseases.
心血管代谢疾病，如 2 型糖尿病（DM）和心血管疾病（CVD），是一个严重的健康问题。旨在提高认识和预防的策略，结合这些疾病的及时诊断和最佳管理，是提高预期寿命和生活质量的主要行动方向。近年来，针对 DM 和 CVD 的治疗的创新疗法的引入为高危患者带来了新的希望。然而，在实现心血管代谢健康方面，预防措施的实施远未成功，需要进一步改进。心血管代谢紊乱的发展是一个复杂的、多因素的过程，涉及多个代谢途径以及遗传和环境因素。减少整个生命过程中的累积暴露，并及时识别和针对潜在的风险增强因素，可能为更成功地预防心血管代谢紊乱铺平道路。如今，在“组学”技术时代，可以识别新的生物标志物和治疗靶点，这为每位患者应用个体化方法提供了可能。这篇综述将讨论基因组、转录组、表观基因组和代谢组生物标志物在心血管代谢疾病个体化预防中的潜在应用。
