2型糖尿病研究中的多重生物标志物方法。

Multiplex Biomarker Approaches in Type 2 Diabetes Mellitus Research.

作者信息

Ozanne Susan E, Rahmoune Hassan, Guest Paul C

机构信息

University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QR, UK.

出版信息

Methods Mol Biol. 2017;1546:37-55. doi: 10.1007/978-1-4939-6730-8_3.

DOI:10.1007/978-1-4939-6730-8_3

PMID:27896756

Abstract

Type 2 diabetes mellitus is a multifactorial condition resulting in high fasting blood glucose levels. Although its diagnosis is straightforward, there is not one set of biomarkers or drug targets that can be used for classification or personalized treatment of individuals who suffer from this condition. Instead, the application of multiplex methods incorporating a systems biology approach is essential in order to increase our understanding of this disease. This chapter reviews the state of the art in biomarker studies of human type 2 diabetes from a proteomic and metabolomic perspective. Our main focus was on biomarkers for disease prediction as these could lead to early intervention strategies for the best possible patient outcomes.

摘要

2型糖尿病是一种导致空腹血糖水平升高的多因素病症。尽管其诊断方法简单直接，但没有一套生物标志物或药物靶点可用于对患有这种病症的个体进行分类或个性化治疗。相反，采用系统生物学方法的多重检测方法的应用对于增进我们对这种疾病的了解至关重要。本章从蛋白质组学和代谢组学的角度综述了人类2型糖尿病生物标志物研究的现状。我们主要关注疾病预测生物标志物，因为这些标志物可能会带来早期干预策略，从而实现最佳的患者治疗效果。