Department of Life Science, CHRIST (Deemed to be University), Bangalore Central Campus, Karnataka, India.
Department of Zoology, St. Joseph's University, Bengaluru, India.
Adv Wound Care (New Rochelle). 2024 Feb;13(2):83-96. doi: 10.1089/wound.2022.0142. Epub 2023 Jun 30.
To conduct a systematic literature review to study the effects of fish-based biomaterials on wound healing in both and animal models. This review covers the study reported in different articles between 2016 and August 2022 concentrating mainly on the cytotoxicity evaluation of different fish-based biomaterials on inflammation, reepithelialization and wound healing. This review shows considerable amount of research work carried out with fish-based biomaterials and collagen for treating burn wounds. Surprisingly there are only a few commercial products developed so far in this particular regard for surgical purpose and therefore, there is a way out and need for developing medical support product from fish-based biomaterials to treat and cure wounds. Three-dimensional skin bioprinting technique is a large-scale solution for severe burn wounds that requires collagen as a raw material for printing, wherein fish collagen can be used in place of bovine and porcine, as it is biocompatible, promotes cell proliferation, adhesion, and migration, and degrades enzymatically. In the recent times, there are a few fish-based surgical products that have been formulated by Kerecis in United States. The different fish-based biomaterial products are all mere supplements taken in orally as food or supplements till date and there is no proper proven medications that has been formulated so far in the field of wound healing and inflammation based on fish biomaterials except the surgical products that can be finger counted. Fish-based biomaterials are known for the medicinal properties that are used throughout the world and further investigations should be carried out to understand the actual physiochemical properties of its derivatives for the discovery of novel products and drugs.
进行系统文献综述，研究基于鱼类的生物材料对 和 动物模型中伤口愈合的影响。本综述涵盖了 2016 年至 2022 年 8 月期间不同文章中报道的研究，主要集中于评估不同基于鱼类的生物材料对炎症、再上皮化和伤口愈合的细胞毒性。本综述显示了相当数量的研究工作，这些工作是使用基于鱼类的生物材料和胶原蛋白治疗烧伤伤口。令人惊讶的是，到目前为止，在这方面专门用于外科手术的商业产品很少，因此，需要开发基于鱼类生物材料的医疗支持产品来治疗和治愈伤口。三维皮肤生物打印技术是一种大规模治疗严重烧伤伤口的解决方案，需要胶原蛋白作为打印的原材料，其中鱼胶原蛋白可以替代牛和猪胶原蛋白，因为它具有生物相容性，能促进细胞增殖、黏附和迁移，并能酶解。在最近，有一些基于鱼类的外科手术产品已经由美国的 Kerecis 公司开发。不同的基于鱼类的生物材料产品迄今仅作为口服的食物或补充剂使用，除了可以用手指计数的外科手术产品外，在基于鱼类生物材料的伤口愈合和炎症领域，没有开发出适当的、经过验证的药物。基于鱼类的生物材料因其药用特性而闻名于世，应该进行进一步的研究，以了解其衍生物的实际物理化学特性，从而发现新的产品和药物。
