Heinicke H J
Z Urol Nephrol. 1986 Mar;79(3):163-9.
It is reported on long-term courses in five patients with Wegener's granulomatosis. Under a treatment with glucocorticoids and immunosuppressive agents lasting several years in all cases a remission developed. In these cases the participation of the kidneys is fateful, whereby from the very beginning a large proportion of sclerosing glomeruli lead to a greater healing of the defect. While the troubles of the patients under the apparently at present unspecific effect of high doses of prednisolone disappear within a few weeks, the onset of the remission lasts at least nine months. It is tried to form criteria which indicate a remission. The treatment with a low maintenance dose for at least one year after the remission seems to be justified in consideration of the frequency of recidivations.
本文报道了5例韦格纳肉芽肿患者的长期病程。所有病例均接受了数年的糖皮质激素和免疫抑制剂治疗，随后病情缓解。在这些病例中，肾脏受累情况至关重要，从一开始就有很大比例的硬化性肾小球导致缺损愈合。虽然患者在高剂量泼尼松龙目前明显非特异性作用下的症状在几周内消失，但缓解的开始至少持续9个月。本文试图制定出表明缓解的标准。考虑到复发频率，缓解后至少用低维持剂量治疗一年似乎是合理的。
