Sabitov A U, Kovtun O P, Esaulenko E V, Sorokin P V
Ural State Medical University.
Saint Petersburg State Pediatric Medical University.
Ter Arkh. 2022 Dec 26;94(11):1278-1284. doi: 10.26442/00403660.2022.11.201979.
Confirmation of the efficacy and safety of the drug riamilovir (Triazavirin), 100 mg capsules, in children aged 12-17 years with the diagnosis of acute viral respiratory infection (ARVI).
The multicenter study included 269 patients diagnosed with acute viral respiratory infection (ICD-10 code: J00, J02, J02.9, J04, J04.0, J04.1, J04.2, J06, J06.0, J06.9) in the presence of clinical manifestations and confirmation of the etiology of the disease by laboratory tests (PCR method). Patients were included in the study after one of the patient's parents/adoptive parents and the patient signed an informed consent to participate in the study. The interval between the appearance of the first symptoms of the disease and the inclusion of the patient in the study did not exceed 36 hours.
As a result of a clinical study, the efficacy and safety of treatment with riamilovir (Triazavirin) in sick children aged 12-17 years with a diagnosis of ARVI was shown. A decrease in the duration of the disease was shown when using the drug riamilovir (Triazavirin) compared with the control group. No serious adverse events were detected during the study.
As a result of the conducted clinical study, the high efficacy, safety and good tolerability of the drug riamilovir in the treatment of children aged 12-17 years with a diagnosis of ARVI was established. It is recommended to use the drug riamilovir in clinical practice as an etiotropic therapy in children aged 12-17 years with a diagnosis of ARVI due to its high efficacy and safety.
证实100毫克胶囊剂瑞米洛韦(三氮唑核苷)治疗12至17岁诊断为急性病毒性呼吸道感染(ARVI)儿童的有效性和安全性。
这项多中心研究纳入了269例诊断为急性病毒性呼吸道感染(ICD-10编码:J00、J02、J02.9、J04、J04.0、J04.1、J04.2、J06、J06.0、J06.9)且有临床表现并通过实验室检测(PCR法)确诊疾病病因的患者。在患者的父母/养父母之一和患者签署参与研究的知情同意书后,将患者纳入研究。疾病首发症状出现至患者纳入研究的间隔时间不超过36小时。
临床研究结果表明,瑞米洛韦(三氮唑核苷)治疗12至17岁诊断为ARVI的患病儿童有效且安全。与对照组相比,使用瑞米洛韦(三氮唑核苷)药物时疾病持续时间缩短。研究期间未检测到严重不良事件。
通过开展的临床研究,证实了瑞米洛韦药物治疗12至17岁诊断为ARVI儿童具有高效性、安全性和良好耐受性。鉴于其高效性和安全性,建议在临床实践中使用瑞米洛韦药物对12至17岁诊断为ARVI的儿童进行病因特异性治疗。