From the Division of Nephrology, Department of Pediatrics, Rush University Medical Center, Chicago IL.
Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Pediatr Emerg Care. 2023 Sep 1;39(9):707-714. doi: 10.1097/PEC.0000000000002949. Epub 2023 May 17.
Current conventional formulas do not predict the expected changes in serum sodium after administration of various fluids to correct serum sodium abnormalities. The Adrogué-Madias formula is currently the preferred and widely used fluid prescription for adult patients with dysnatremias, but its therapeutic efficacy has not been validated in pediatric patients.
In this prospective study, we used the Adrogué-Madias formula for calculating the appropriate rate of various fluids administration to correct serum sodium abnormalities in 7 critically ill children with acute dysnatremias.
After administration of various intravenous fluids using the Adrogué-Madias formula, the anticipated as well as the achieved sodium concentrations were almost similar.
This study demonstrates that the use of the Adrogué-Madias quantitative formula allows to calculate the appropriate rate of administration of various fluids. The calculated fluid administration resulted in the subsequent actual laboratory values and clinical changes.
目前的常规公式无法预测在给予各种液体以纠正血清钠异常后血清钠的预期变化。Adrogué-Madias 公式目前是治疗成人电解质紊乱患者的首选和广泛使用的液体处方，但尚未在儿科患者中验证其治疗效果。
在这项前瞻性研究中，我们使用 Adrogué-Madias 公式计算了 7 例患有急性电解质紊乱的危重病儿给予各种静脉液体的适当输注率，以纠正血清钠异常。
使用 Adrogué-Madias 公式给予各种静脉液体后，预期的和实际的钠浓度非常相似。
本研究表明，使用 Adrogué-Madias 定量公式可以计算各种液体的适当输注率。计算出的液体输注量导致了随后的实际实验室值和临床变化。
