Department of Nephrology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Department of Nephrology, Gelre Hospital, Apeldoorn, The Netherlands.
PLoS One. 2021 Jan 15;16(1):e0245499. doi: 10.1371/journal.pone.0245499. eCollection 2021.
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is one of the most common causes of hypotonic hyponatremia. In our previous work, we have derived a novel model (Voets equation) that can be used by clinicians to predict the effect of crystalloid intravenous fluid therapy on the plasma sodium concentration in SIADH.
In this retrospective chart review, the predictive accuracy of the Voets equation and the Adrogue-Madias equation for the plasma sodium response to crystalloid infusate was compared for fifteen plasma sodium response measurements (n = 15) in twelve SIADH patients. The medical records of these patients were accessed anonymously and none of the authors were their treating physicians. The Pearson correlation coefficient r and corresponding p-value were calculated for the predictions by the Voets model compared to the measured plasma sodium response and for the predictions by the Adrogue-Madias model compared to the measured plasma sodium response.
The presented results show that the Voets model (r = 0.94, p < 0.001) predicted the aforementioned plasma sodium response significantly more accurately than the Adrogue-Madias model (r = 0.49, p = 0.07) in SIADH patients and could therefore be a clinically useful addition to the existing prediction models.
抗利尿激素分泌不当综合征（SIADH）是低张性低钠血症最常见的原因之一。在我们之前的工作中，已经推导出了一个新的模型（Voets 方程），可以供临床医生用于预测晶体液静脉输液治疗对 SIADH 患者血浆钠离子浓度的影响。
在这项回顾性图表研究中，比较了 Voets 方程和 Adrogue-Madias 方程对 12 例 SIADH 患者的 15 次血浆钠离子反应测量值（n=15）的晶体液输入对血浆钠离子反应的预测准确性。这些患者的病历被匿名获取，而且没有作者是他们的治疗医生。计算了 Voets 模型预测值与实测血浆钠离子反应之间的 Pearson 相关系数 r 和相应的 p 值，以及 Adrogue-Madias 模型预测值与实测血浆钠离子反应之间的 Pearson 相关系数 r 和相应的 p 值。
研究结果表明，Voets 模型（r=0.94，p<0.001）在 SIADH 患者中对上述血浆钠离子反应的预测准确性明显高于 Adrogue-Madias 模型（r=0.49，p=0.07），因此可以成为现有预测模型的有用补充。
