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[医院内首次发作肺栓塞的治疗。抗凝剂、抗血小板聚集药物及溶栓剂]

[Treatment of the first episode of pulmonary embolism in the hospital. Anticoagulants, anti-platelet aggregation drugs and thrombolysis stimulants].

作者信息

Moriau M, Lavenne-Pardonge E, Col-De Beys C, Jaumin P, el Gariani A, Rubay J, Goenen M

出版信息

Acta Chir Belg. 1986 Mar-Apr;86(2):97-105.

PMID:3716728
Abstract

The treatment of the first pulmonary embolic accident in Hospital consist in the administration of anticoagulants. Heparin will be first used intravenously or subcutaneously during 10 to 12 days and will be followed by oral anticoagulants (VKA) during 3 to 12 months. These treatments must be controlled following national or international standardized technics and can be associated with antiplatelet drugs or thrombolytic activators. The most important and frequent complications observed are haemorrhages. They are consecutive to a non conformed administration of the drugs or overdosage bound to a non correct control or drugs interferences or to a misappreciated counterindication. They will be corrected in most of the cases by a simple anticoagulant dosage reduction and exceptionally by the interruption of the therapy with administration of antidotes and plasma substitutes. Other complications are extremely rare and bound to the nature of the drugs used.

摘要

在医院,首次肺栓塞事件的治疗包括给予抗凝剂。首先,肝素将在10至12天内静脉或皮下使用,随后在3至12个月内使用口服抗凝剂(维生素K拮抗剂)。这些治疗必须按照国家或国际标准化技术进行监测,并且可以与抗血小板药物或溶栓激活剂联合使用。观察到的最重要且最常见的并发症是出血。它们是由于药物使用不当、因控制不当、药物相互作用或禁忌证判断错误导致的过量用药所致。在大多数情况下,通过简单减少抗凝剂剂量即可纠正,极少数情况下则需中断治疗并给予解毒剂和血浆代用品。其他并发症极为罕见,且与所用药物的性质有关。

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