School of Materials Science, Indian Association for the Cultivation of Science, Kolkata 700032, India.
Department of Chemistry, University of Houston, Houston, Texas 77204-5003, United States.
ACS Appl Bio Mater. 2023 Jun 19;6(6):2102-2110. doi: 10.1021/acsabm.2c00771. Epub 2023 May 11.
Trehalose is a disaccharide that is capable of inhibiting protein aggregation and activating cellular autophagy. It has been shown that a polymer or nanoparticle form, terminated with multiple trehalose units, can significantly enhance the anti-amyloidogenic performance and is suitable for the treatment of neurodegenerative diseases. Here, we report a trehalose-conjugated polycarbonate--lactide polymer and formulation of its nanoparticles having multiple numbers of trehalose exposed on the surface. The resultant poly(trehalose) nanoparticle inhibits the aggregation of amyloid beta peptides and disintegrates matured amyloid fibrils into smaller fragments. Moreover, the poly(trehalose) nanoparticle lowers extracellular amyloid β oligomer-driven cellular stress and enhances cell viability. The presence of biodegradable polycarbonate components in the poly(trehalose) nanoparticle would enhance their application potential as an anti-amyloidogenic material.
海藻糖是一种二糖，能够抑制蛋白质聚集并激活细胞自噬。已经表明，具有多个海藻糖单元的聚合物或纳米颗粒形式可以显著增强抗淀粉样变性性能，并且适合治疗神经退行性疾病。在这里，我们报告了一种海藻糖缀合的聚碳酸酯-丙交酯聚合物及其具有多个表面暴露的海藻糖的纳米颗粒制剂。所得的聚（海藻糖）纳米颗粒抑制淀粉样β肽的聚集并将成熟的淀粉样纤维分解成较小的片段。此外，聚（海藻糖）纳米颗粒降低了细胞外淀粉样β低聚物驱动的细胞应激并提高了细胞活力。聚（海藻糖）纳米颗粒中存在可生物降解的聚碳酸酯成分将增强它们作为抗淀粉样变性材料的应用潜力。
