Ushijima M, Hashimoto H, Tsuneyoshi M, Enjoji M
Acta Pathol Jpn. 1986 Mar;36(3):317-26. doi: 10.1111/j.1440-1827.1986.tb01022.x.
Clinicopathologic, enzyme histochemical and electron microscopic findings in 52 patients with pigmented villonodular synovitis (PVS) are reported. The lesion was by far the most common in the knee joint (48%), followed by the ankle joint (25%). As to sex incidence, there seemed to be no predilection (46% in men, 54% in women). Microscopically, the PVS showed thin or thick villous projections of the involved synovial membrane, associated with or without nodular formation. The nodule of PVS consisted essentially of a proliferation of histiocyte-like cells with phagocytic activities. Another characteristic feature was large clefts and pseudoglandular or alveolar spaces lined by synovial cells. Enzyme histochemical studies revealed that the lesional cells had functional properties of macrophages. Electron microscopically, the lesion consisted essentially of histiocyte-like and fibroblast-like cells, together with intermediate cells and myofibroblasts.
报告了52例色素沉着绒毛结节性滑膜炎（PVS）患者的临床病理、酶组织化学及电子显微镜检查结果。该病变在膝关节最为常见（48%），其次是踝关节（25%）。在性别发病率方面，似乎没有明显偏好（男性46%，女性54%）。显微镜下，PVS表现为受累滑膜的薄或厚绒毛状突起，伴有或不伴有结节形成。PVS结节主要由具有吞噬活性的组织细胞样细胞增殖组成。另一个特征性表现是有大的裂隙以及由滑膜细胞衬里的假腺泡或肺泡样间隙。酶组织化学研究显示病变细胞具有巨噬细胞的功能特性。电子显微镜检查发现，病变主要由组织细胞样和成纤维细胞样细胞组成，还有中间细胞和肌成纤维细胞。
