Ushijima M, Hashimoto H, Tsuneyoshi M, Enjoji M
Cancer. 1986 Feb 15;57(4):875-84. doi: 10.1002/1097-0142(19860215)57:4<875::aid-cncr2820570432>3.0.co;2-y.
Clinicopathologic, enzyme histochemical, and electron microscopic findings in 207 cases (208 lesions) of giant cell tumor of tendon sheath (GCTTS) are presented. The GCTTS could be divided into two groups according to the anatomic location, the first occurring in the digits (digit group, 182 cases) and the second, in the larger joints (large joint group, 25 cases). In the majority of cases of the digit group, the tumor occurred in one of the fingers (158 cases), whereas in the large joint group, the tumor was common in the ankle (10 cases) and knee joints (8 cases). The lesion was more common in women (67%) than in men (33%). Microscopically, the GCTTS in both groups consisted of a mixture of abundant histiocyte-like, foam, and multinucleated giant cells of the osteoclast type. However, worthy of special mention were the large clefts or wide pseudoglandular spaces lined by synovial cells and that were more striking in the large joint group than in the conventional digit group. The component cells had functional properties of macrophages, as determined in the enzyme histochemical study. Electron microscopically, the tumors consisted essentially of histiocyte-like, fibroblast-like, and intermediate cells, together with myofibroblasts.
本文报告了207例（208个病灶）腱鞘巨细胞瘤（GCTTS）的临床病理、酶组织化学及电子显微镜检查结果。根据解剖位置，GCTTS可分为两组，第一组发生于手指（指部组，182例），第二组发生于较大关节（大关节组，25例）。在指部组的大多数病例中，肿瘤发生于某一手指（158例），而在大关节组中，肿瘤常见于踝关节（10例）和膝关节（8例）。该病变在女性中（67%）比男性中（33%）更常见。显微镜下，两组的GCTTS均由丰富的组织细胞样、泡沫样及破骨细胞型多核巨细胞混合组成。然而，值得特别提及的是由滑膜细胞衬覆的大裂隙或宽假腺腔隙，在大关节组中比在传统指部组中更显著。酶组织化学研究表明，组成细胞具有巨噬细胞的功能特性。电子显微镜检查显示，肿瘤主要由组织细胞样、成纤维细胞样及中间型细胞以及肌成纤维细胞组成。
