西罗莫司（雷帕霉素）诱导抗肿瘤坏死因子难治性小儿溃疡性结肠炎的黏膜愈合。
Sirolimus (Rapamycin) Induced Mucosal Healing in Anti-Tumor Necrosis Factor Refractory Pediatric Ulcerative Colitis.
作者信息
Kellermayer Richard, Chang Andrew, Patel Kalyani
机构信息
Section of Pediatric Gastroenterology, Texas Children's Hospital Baylor College of Medicine.
USDA/ARS Children's Nutrition Research Center.
出版信息
JPGN Rep. 2022 Mar 17;3(2):e183. doi: 10.1097/PG9.0000000000000183. eCollection 2022 May.
Sirolimus (rapamycin) has been sparsely reported in the treatment of pediatric ulcerative colitis (PUC). Mucosal healing has not been examined in responders to the drug. We describe a case of infliximab refractory PUC where rapamycin induced sustained clinical remission along with mucosal healing. We conclude that rapamycin should be positioned into the expanding treatment repertoire of PUC.
西罗莫司（雷帕霉素）用于治疗儿童溃疡性结肠炎（PUC）的报道较少。尚未对该药物治疗有效的患者进行黏膜愈合情况的检查。我们描述了1例英夫利昔单抗难治性PUC病例，雷帕霉素诱导了持续的临床缓解并伴有黏膜愈合。我们得出结论，雷帕霉素应纳入不断扩大的PUC治疗方法中。
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