Metaxas Georgios I, Spyropoulou Despoina, Mastronikoli Sofianiki, Tsiambas Evangelos, Falidas Evangelos, Marinopoulos Spyridon, Manaios Loukas, Davris Dimitrios, Fotiades Panagiotis, Peschos Dimitrios, Dimitrakakis Constantine
Breast Unit, 1st Department of Obstetrics and Gynaecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Department of Radiation Oncology, Medical School, University of Patras, Patras, Greece.
Cancer Diagn Progn. 2023 May 3;3(3):297-301. doi: 10.21873/cdp.10215. eCollection 2023 May-Jun.
Calpains belong to a family of important calcium-dependent cysteine proteases. They are involved in intracellular processes including cytoskeleton disorganization and substrate proteolysis. They also enhance apoptosis and cell to cell adhesion. Calpains demonstrate also a mechanosensory function in neoplastic and malignant cells due to their implication in mechanoptosis. This is a specific type of apoptotic death induced by strong external mechanical stimuli. Anti-cytoskeleton rigidity inhibition strategies based on calpain induction lead to increased apoptosis of tumor transformed cells. Elevated intracellular calcium concentration mediated by specific receptors and channels activates calpains. In the current molecular review, we explored the role of calpains in calcium-dependent signa transduction pathways in breast adenocarcinoma in conjunction with novel agents that activate their important anti-tumor functions.
钙蛋白酶属于一类重要的钙依赖性半胱氨酸蛋白酶家族。它们参与细胞内过程，包括细胞骨架紊乱和底物蛋白水解。它们还能增强细胞凋亡和细胞间粘附。由于钙蛋白酶参与机械性细胞凋亡，因此在肿瘤细胞和恶性细胞中也表现出机械传感功能。这是一种由强烈外部机械刺激诱导的特定类型的凋亡死亡。基于钙蛋白酶诱导的抗细胞骨架刚性抑制策略会导致肿瘤转化细胞的凋亡增加。由特定受体和通道介导的细胞内钙浓度升高会激活钙蛋白酶。在当前的分子综述中，我们结合激活其重要抗肿瘤功能的新型药物，探讨了钙蛋白酶在乳腺腺癌钙依赖性信号转导途径中的作用。
