Department of Emergency Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Department of Emergency Medicine, People's Hospital of Bortala Mongol Autonomous Prefecture, Bole, China.
Front Endocrinol (Lausanne). 2023 Apr 14;14:1124041. doi: 10.3389/fendo.2023.1124041. eCollection 2023.
E3 ubiquitin ligases are important components of the ubiquitin protease system. This family includes many proteins, which can catalyze the ubiquitination of a variety of protein substrates and promote the degradation of them by the proteasome system. Recent studies have shown that E3 ubiquitin ligase plays a key role in the process of fetal development and placental formation. It affects the biological behavior of placental trophoblast cells, leading to a series of pregnancy complications that threaten mothers and babies greatly. This review focuses on the regulation, target and mechanism of E3 ubiquitin ligase on the biological behavior of human placental trophoblast cells.
E3 泛素连接酶是泛素蛋白酶体系统的重要组成部分。该家族包括许多蛋白质，可催化多种蛋白质底物的泛素化，并促进它们被蛋白酶体系统降解。最近的研究表明，E3 泛素连接酶在胎儿发育和胎盘形成过程中发挥着关键作用。它影响胎盘滋养层细胞的生物学行为，导致一系列严重威胁母婴的妊娠并发症。本综述重点介绍 E3 泛素连接酶对人胎盘滋养层细胞生物学行为的调节、靶标和机制。
