Universidade Federal de Mato Grosso (UFMT), Faculdade de Medicina, Departamento de Pediatria, Cuiabá, MT, Brazil.
Universidade Federal de Mato Grosso (UFMT), Faculdade de Medicina, Departamento de Pediatria, Cuiabá, MT, Brazil.
J Pediatr (Rio J). 2023 Sep-Oct;99(5):492-499. doi: 10.1016/j.jped.2023.03.007. Epub 2023 May 8.
To determine reference intervals (RI) for serum immunoglobulin A (IgA) levels in healthy children aged 1 to 1 0 years residing in the central region of Brazil.
This cross-sectional study was conducted on 1,743 healthy children randomly selected from kindergartens and public schools in Cuiabá, MT, Brazil. The IgA RIs were defined using the statistical methods postulated by the guidelines of the United States Clinical and Laboratory Standards Institute, the nonparametric bootstrap method, and Horn's robust method after the correction of discrepancies by Tukey's, Dixon's, and Horn's methods, respectively. The results were defined based on the values contained between the 2.5th and 97.5th percentiles and their respective 95% confidence intervals.
Partition by sex was not necessary to determine the IgA RI of the studied children. Homogeneous subgroups were identified among children aged 1-<2, 2-<5, and 5-<11 years, whose IgA-specific RIs were determined.
The serum IgA RIs were established for three groups of Brazilian children aged 1-11 years, which differed from those currently applied in Brazilian pediatric practice and from those defined by international studies. This definition will help Brazilian pediatricians formulate an accurate diagnosis and facilitate decision-making.
确定巴西中部地区 1 至 10 岁健康儿童的血清免疫球蛋白 A（IgA）水平参考区间（RI）。
本横断面研究在巴西马托格罗索州库亚巴市的幼儿园和公立学校中随机抽取了 1743 名健康儿童。采用美国临床和实验室标准协会的指导方针、非参数自举法和 Horn 的稳健方法分别通过 Tukey、Dixon 和 Horn 方法校正差异后定义 IgA RI。结果根据第 2.5 至 97.5 百分位数及其各自 95%置信区间内的值定义。
按性别划分不需要确定所研究儿童的 IgA RI。在 1-<2 岁、2-<5 岁和 5-<11 岁的儿童中确定了同质亚组，其 IgA 特异性 RI 不同。
为 1-11 岁的三组巴西儿童建立了血清 IgA RI，与目前在巴西儿科实践中应用的 RI 以及国际研究中定义的 RI 不同。这一定义将有助于巴西儿科医生做出准确诊断和决策。
