Obiandu C, Okerengwo A A, Dapper D V
Hemorheology Research Unit, Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, PMB 5323, Port Harcourt, Nigeria.
Niger J Physiol Sci. 2013 Jun 30;28(1):23-7.
Serum levels of the immunoglobulins: IgG, IgA and IgM were determined by the single radial immunodiffusion technique of Mancini in a total of 122 apparently healthy subjects consisting of 43 children (20 males; 23 females) aged 5-12 years and 79 adults (39 males; 40 females) aged 18-65 years resident in Port Harcourt, southeastern Nigeria. The effects of age and sex on the serum levels of the various immunoglobulin types were also determined. The mean values and ranges for the various immunoglobulin types are presented for both children and adults. Although, female children were found to have significantly lower mean values of IgA compared to male children (p<0.05), there were no significant differences in the mean values of both IgG and IgM between male and female children involved in the present study (p>0.05). However, female adults had significantly higher mean values of IgG and significantly lower mean values of IgA compared to male adults (p<0.05); suggesting a significant gender difference in the value of both IgG and IgA amongst adult subjects. No significant differences were observed in the mean values of any of the various types of immunoglobulin between adults and children. The present study reports mean values of the various types of immunoglobulin in apparently healthy children and adults resident in Port Harcourt, southeastern Nigeria. Significant gender differences were observed for some of the immunoglobulin types only amongst adults. Our results suggest that these gender differences amongst adults were apparently a gradual build-up from childhood. The results also confirm suggestions that levels of some immunoglobulin types seen amongst African adults may have possibly been attained during childhood. Our study could be of value since previous reports in this regard have been relatively scanty especially in this part of Nigeria.
采用曼西尼单向放射免疫扩散技术测定了122名表面健康受试者的血清免疫球蛋白水平：IgG、IgA和IgM。这些受试者来自尼日利亚东南部哈科特港，包括43名5至12岁的儿童（20名男性，23名女性）和79名18至65岁的成年人（39名男性，40名女性）。同时还测定了年龄和性别对各种免疫球蛋白类型血清水平的影响。列出了儿童和成人各种免疫球蛋白类型的平均值和范围。尽管发现女童的IgA平均值显著低于男童（p<0.05），但本研究中参与的男童和女童的IgG和IgM平均值均无显著差异（p>0.05）。然而，成年女性的IgG平均值显著高于成年男性，而IgA平均值显著低于成年男性（p<0.05）；这表明成年受试者中IgG和IgA的值存在显著的性别差异。在成人和儿童之间，未观察到任何类型免疫球蛋白平均值的显著差异。本研究报告了尼日利亚东南部哈科特港表面健康儿童和成人各种免疫球蛋白类型的平均值。仅在成年人中观察到某些免疫球蛋白类型存在显著的性别差异。我们的结果表明，成年人中的这些性别差异显然是从儿童时期逐渐积累起来的。结果还证实了一些观点，即非洲成年人中某些免疫球蛋白类型的水平可能在儿童时期就已达到。我们的研究可能具有价值，因为此前关于这方面的报告相对较少，尤其是在尼日利亚的这一地区。
