State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian, 116024, China.
Department of Interventional Therapy, Cancer Hospital of, Dalian University of Technology, Liaoning Cancer Hospital and Institute, Shenyang, 110042, China.
Chembiochem. 2023 Aug 15;24(16):e202300323. doi: 10.1002/cbic.202300323. Epub 2023 Jul 13.
Photodynamic therapy (PDT) is one common ROS-generating therapeutic method with high tumor selectivity and low side effects. But the GSH-upregulation often alleviates its therapeutic efficiency. Here, we proposed a new strategy of jointly depleting GSH to enhance the therapeutic effect of PDT by preparing a nanomicelle by self-assembly method from GSH-activated photosensitizer DMT, curcumin, and amphiphilic polymer TPGS.
光动力疗法（PDT）是一种常见的 ROS 生成治疗方法，具有高肿瘤选择性和低副作用。但 GSH 的上调常常会减轻其治疗效果。在这里，我们提出了一种新的策略，即通过自组装方法将 GSH 激活的光敏剂 DMT、姜黄素和两亲性聚合物 TPGS 制备成纳米胶束，共同耗竭 GSH 以增强 PDT 的治疗效果。
