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异基因造血干细胞移植后播散性内脏卡波西肉瘤:一例报告。

Disseminated visceral Kaposi's sarcoma after allogeneic hematopoietic stem cell transplantation: a case report.

机构信息

Department of Medicine, Shihezi University, Xinjiang, China.

Department of Haematology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.

出版信息

J Int Med Res. 2023 May;51(5):3000605231172871. doi: 10.1177/03000605231172871.

Abstract

Cases of disseminated visceral Kaposi's sarcoma (KS) after allogenic hematopoietic stem cell transplantation (HSCT) are very rare worldwide, and disseminated visceral KS is often rapidly progressive and life-threatening, especially in paediatric patients. Here, the case of a 6-year-old female patient with disseminated visceral KS after allogeneic HSCT for treating severe aplastic anaemia is presented. The authors encountered difficulties in making the diagnosis due to lack of experience, but the diagnosis was achieved relatively quickly and accurately using metagenomic next-generation sequencing. After tapering and withdrawal of immunosuppressant drugs, the patient's condition was controlled. In conclusion, although HSCT-related KS is very rare, it should be considered during differential diagnosis.

摘要

异基因造血干细胞移植(HSCT)后发生弥漫性内脏卡波西肉瘤(KS)的病例在全球范围内非常罕见,弥漫性内脏 KS 通常进展迅速且危及生命,尤其是在儿科患者中。在此,报告了一例 6 岁女性患者,因严重再生障碍性贫血行异基因 HSCT 后发生弥漫性内脏 KS。由于经验不足,作者在诊断时遇到了困难,但使用宏基因组二代测序相对快速和准确地做出了诊断。在逐渐减少和停用免疫抑制剂后,患者的病情得到了控制。总之,尽管 HSCT 相关 KS 非常罕见,但在鉴别诊断中应考虑到这一点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce52/10184207/68e80ffe70ee/10.1177_03000605231172871-fig1.jpg

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