Using conditional inference to quantify interaction effects of socio-demographic covariates of US COVID-19 vaccine hesitancy.

COVID-19 vaccine hesitancy has become a major issue in the U.S. as vaccine supply has outstripped demand and vaccination rates slow down. At least one recent global survey has sought to study the covariates of vaccine acceptance, but an inferential model that makes simultaneous use of several socio-demographic variables has been lacking. This study has two objectives. First, we quantify the associations between common socio-demographic variables (including, but not limited to, age, ethnicity, and income) and vaccine acceptance in the U.S. Second, we use a conditional inference tree to quantify and visualize the interaction and conditional effects of relevant socio-demographic variables, known to be important correlates of vaccine acceptance in the U.S., on vaccine acceptance. We conduct a retrospective analysis on a COVID-19 cross-sectional Gallup survey data administered to a representative sample of U.S.-based respondents. Our univariate regression results indicate that most socio-demographic variables, such as age, education, level of household income and education, have significant association with vaccine acceptance, although there are key points of disagreement with the global survey. Similarly, our conditional inference tree model shows that trust in the (former) Trump administration, age and ethnicity are the most important covariates for predicting vaccine hesitancy. Our model also highlights the interdependencies between these variables using a tree-like visualization.