遗传结构在表型可塑性中的作用。

Role of genetic architecture in phenotypic plasticity.

机构信息

Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, IIT Madras, Chennai, India; Centre for Integrative Biology and Systems mEdicine (IBSE), IIT Madras, Chennai, India; Robert Bosch Centre for Data Science and Artificial Intelligence (RBCDSAI), IIT Madras, Chennai, India.

Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

出版信息

Trends Genet. 2023 Sep;39(9):703-714. doi: 10.1016/j.tig.2023.04.002. Epub 2023 May 10.

DOI:10.1016/j.tig.2023.04.002

PMID:37173192

Abstract

Phenotypic plasticity, the ability of an organism to display different phenotypes across environments, is widespread in nature. Plasticity aids survival in novel environments. Herein, we review studies from yeast that allow us to start uncovering the genetic architecture of phenotypic plasticity. Genetic variants and their interactions impact the phenotype in different environments, and distinct environments modulate the impact of genetic variants and their interactions on the phenotype. Because of this, certain hidden genetic variation is expressed in specific genetic and environmental backgrounds. A better understanding of the genetic mechanisms of phenotypic plasticity will help to determine short- and long-term responses to selection and how wide variation in disease manifestation occurs in human populations.

摘要

表型可塑性，即生物体在不同环境中表现出不同表型的能力，在自然界中广泛存在。可塑性有助于生物体在新环境中生存。本文综述了来自酵母的研究，这些研究使我们开始揭示表型可塑性的遗传结构。遗传变异及其相互作用影响不同环境中的表型，而不同的环境会调节遗传变异及其相互作用对表型的影响。因此，某些隐藏的遗传变异在特定的遗传和环境背景中表达。更好地理解表型可塑性的遗传机制将有助于确定对选择的短期和长期反应，以及人类群体中疾病表现的广泛变异是如何发生的。