文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

2022 年医药市场获批新药：含定制氨基酸片段和氟的新药。

New Approved Drugs Appearing in the Pharmaceutical Market in 2022 Featuring Fragments of Tailor-Made Amino Acids and Fluorine.

机构信息

Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.

School of Allied Medical Sciences, Delhi Skill and Entrepreneurship University, Dwarka, New Delhi 110075, India.

出版信息

Molecules. 2023 Apr 22;28(9):3651. doi: 10.3390/molecules28093651.

DOI:10.3390/molecules28093651
PMID:37175060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10180415/
Abstract

The strategic fluorination of oxidatively vulnerable sites in bioactive compounds is a relatively recent, widely used approach allowing us to modulate the stability, bio-absorption, and overall efficiency of pharmaceutical drugs. On the other hand, natural and tailor-made amino acids are traditionally used as basic scaffolds for the development of bioactive molecules. The main goal of this review article is to emphasize these general trends featured in recently approved pharmaceutical drugs.

摘要

在生物活性化合物中氧化敏感位点的战略性氟化是一种相对较新的、广泛应用的方法，可用于调节药物的稳定性、生物吸收和整体效率。另一方面，天然和定制的氨基酸通常被用作生物活性分子开发的基本支架。本文的主要目的是强调这些在最近批准的药物中体现的总体趋势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/fd43d429298e/molecules-28-03651-sch010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/2cda6935f637/molecules-28-03651-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/724b299e236b/molecules-28-03651-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/1e03547dc550/molecules-28-03651-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/cd70d22a91ee/molecules-28-03651-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/fa241329e4f0/molecules-28-03651-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/f83be210e472/molecules-28-03651-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/280da2537459/molecules-28-03651-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/1ddd73d91dd4/molecules-28-03651-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/be29860ec6cf/molecules-28-03651-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/a7aef3fded2b/molecules-28-03651-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/cae2605d6f22/molecules-28-03651-sch007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/2843859b1d73/molecules-28-03651-sch008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/ee9a71c4c638/molecules-28-03651-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/c5d57d5b9cdf/molecules-28-03651-sch009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/fca3b21b639f/molecules-28-03651-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/fd43d429298e/molecules-28-03651-sch010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/2cda6935f637/molecules-28-03651-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/724b299e236b/molecules-28-03651-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/1e03547dc550/molecules-28-03651-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/cd70d22a91ee/molecules-28-03651-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/fa241329e4f0/molecules-28-03651-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/f83be210e472/molecules-28-03651-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/280da2537459/molecules-28-03651-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/1ddd73d91dd4/molecules-28-03651-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/be29860ec6cf/molecules-28-03651-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/a7aef3fded2b/molecules-28-03651-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/cae2605d6f22/molecules-28-03651-sch007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/2843859b1d73/molecules-28-03651-sch008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/ee9a71c4c638/molecules-28-03651-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/c5d57d5b9cdf/molecules-28-03651-sch009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/fca3b21b639f/molecules-28-03651-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad39/10180415/fd43d429298e/molecules-28-03651-sch010.jpg

相似文献

[1]
New Approved Drugs Appearing in the Pharmaceutical Market in 2022 Featuring Fragments of Tailor-Made Amino Acids and Fluorine.

Molecules. 2023-4-22

[2]
Applications of fluorine-containing amino acids for drug design.

Eur J Med Chem. 2019-11-4

[3]
The Latest FDA-Approved Pharmaceuticals Containing Fragments of Tailor-Made Amino Acids and Fluorine.

Pharmaceuticals (Basel). 2022-8-14

[4]
Practical synthesis of fluorine-containing α- and β-amino acids: recipes from Kiev, Ukraine.

Future Med Chem. 2009-8

[5]
Tailor-made amino acid-derived pharmaceuticals approved by the FDA in 2019.

Amino Acids. 2020-9

[6]
Modern Approaches for Asymmetric Construction of Carbon-Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs.

Chem Rev. 2018-4-2

[7]
Tailor-Made Amino Acids and Fluorinated Motifs as Prominent Traits in Modern Pharmaceuticals.

Chemistry. 2020-9-4

[8]
Tailor-made amino acids in the design of small-molecule blockbuster drugs.

Eur J Med Chem. 2021-8-5

[9]
Tinker, Tailor, Soldier, Spy: The Diverse Roles That Fluorine Can Play within Amino Acid Side Chains.

Molecules. 2023-8-22

[10]
Fluorination methods for drug discovery and development.

Expert Opin Drug Discov. 2016-8-30

引用本文的文献

[1]
Synthesis and biological evaluation of trifluoromethyl-containing auxin derivatives.

J Pestic Sci. 2025-8-20

[2]
Sequential Michael addition, cross-coupling and [3 + 2] cycloaddition reactions within the coordination sphere of chiral Ni(ii) Schiff base complexes derived from dehydroamino acids: pathways to the asymmetric synthesis of structurally diverse -substituted serine and threonine analogs.

RSC Adv. 2025-4-4

[3]
Asymmetric synthesis of fluorinated derivatives of aromatic and γ-branched amino acids via a chiral Ni(II) complex.

Beilstein J Org Chem. 2025-3-21

[4]
Synthesis and application of well-defined [PhP][Cu(CFCF)] complex as a versatile pentafluoroethylating reagent.

Chem Sci. 2024-6-20

[5]
Copper-catalyzed multicomponent reaction of β-trifluoromethyl β-diazo esters enabling the synthesis of β-trifluoromethyl ,-diacyl-β-amino esters.

Beilstein J Org Chem. 2024-2-2

[6]
Monofluoromethylation of -Heterocyclic Compounds.

Int J Mol Sci. 2023-12-18

[7]
Trifluoromethylthiolation of Tryptophan and Tyrosine Derivatives: A Tool for Enhancing the Local Hydrophobicity of Peptides.

J Org Chem. 2023-9-15

[8]
Featured Reviews in Organic Chemistry.

Molecules. 2023-8-9

本文引用的文献

[1]
FDA new drug approvals in Q3 2022.

Nat Rev Drug Discov. 2022-11

[2]
A Comprehensive Review of Daridorexant, a Dual-Orexin Receptor Antagonist as New Approach for the Treatment of Insomnia.

Molecules. 2022-9-16

[3]
The Latest FDA-Approved Pharmaceuticals Containing Fragments of Tailor-Made Amino Acids and Fluorine.

Pharmaceuticals (Basel). 2022-8-14

[4]
Phase 3 study evaluating the safety and efficacy of oteseconazole in the treatment of recurrent vulvovaginal candidiasis and acute vulvovaginal candidiasis infections.

Am J Obstet Gynecol. 2022-12

[5]
Mavacamten: First Approval.

Drugs. 2022-7

[6]
Oteseconazole: First Approval.

Drugs. 2022-6

[7]
Adagrasib in Non-Small-Cell Lung Cancer Harboring a Mutation.

N Engl J Med. 2022-7-14

[8]
Capsid Inhibition with Lenacapavir in Multidrug-Resistant HIV-1 Infection.

N Engl J Med. 2022-5-12

[9]
Daridorexant: First Approval.

Drugs. 2022-4

[10]
PSMA-Targeting Imaging and Theranostic Agents-Current Status and Future Perspective.

Int J Mol Sci. 2022-1-21

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索