2022 年医药市场获批新药：含定制氨基酸片段和氟的新药。
New Approved Drugs Appearing in the Pharmaceutical Market in 2022 Featuring Fragments of Tailor-Made Amino Acids and Fluorine.
机构信息
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
School of Allied Medical Sciences, Delhi Skill and Entrepreneurship University, Dwarka, New Delhi 110075, India.
出版信息
Molecules. 2023 Apr 22;28(9):3651. doi: 10.3390/molecules28093651.
The strategic fluorination of oxidatively vulnerable sites in bioactive compounds is a relatively recent, widely used approach allowing us to modulate the stability, bio-absorption, and overall efficiency of pharmaceutical drugs. On the other hand, natural and tailor-made amino acids are traditionally used as basic scaffolds for the development of bioactive molecules. The main goal of this review article is to emphasize these general trends featured in recently approved pharmaceutical drugs.
在生物活性化合物中氧化敏感位点的战略性氟化是一种相对较新的、广泛应用的方法，可用于调节药物的稳定性、生物吸收和整体效率。另一方面，天然和定制的氨基酸通常被用作生物活性分子开发的基本支架。本文的主要目的是强调这些在最近批准的药物中体现的总体趋势。
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