作为通用五氟乙基化试剂的结构明确的[PhP][Cu(CFCF)]配合物的合成与应用。
Synthesis and application of well-defined [PhP][Cu(CFCF)] complex as a versatile pentafluoroethylating reagent.
作者信息
Dong Tao, Shen Qilong, Tsui Gavin Chit
机构信息
Department of Chemistry, The Chinese University of Hong Kong Shatin, New Territories Hong Kong SAR China
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry 345 Lingling Lu Shanghai 200032 China
出版信息
Chem Sci. 2024 Jun 20;15(29):11550-11556. doi: 10.1039/d4sc02075h. eCollection 2024 Jul 24.
We herein describe the preparation and application of a new bispentafluoroethylated organocuprate [PhP][Cu(CFCF)]. This complex has demonstrated a remarkable range of reactivities towards carboxylic acids, diazonium salts, organic halides, boronic esters, terminal alkynes and (hetero)arenes as a versatile pentafluoroethylating reagent. The construction of C(sp)-/C(sp)-/C(sp)-CFCF bonds can therefore be achieved using a single reagent.
我们在此描述了一种新型双五氟乙基铜酸盐[PhP][Cu(CFCF)]的制备及其应用。作为一种通用的五氟乙基化试剂，该配合物对羧酸、重氮盐、有机卤化物、硼酸酯、末端炔烃和（杂）芳烃表现出广泛的反应活性。因此，使用单一试剂即可实现C(sp)-/C(sp)-/C(sp)-CFCF键的构建。
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