Department of Diagnostics and Public Health, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy.
FOR ALL Srl, Via 8 Marzo 10-12, Bussolengo, 37012 Verona, Italy.
Int J Mol Sci. 2023 May 5;24(9):8331. doi: 10.3390/ijms24098331.
UV radiation is used for sterilization but has adverse health effects in humans. UV-A radiation has lower antimicrobial effect than UV-B and UV-C but constitutes a lower health risk, opening up the possibility to sanitize environments with human presence in controlled exposure conditions. We investigated this possibility by identifying safe exposure conditions to a UV-A lamp along with efficient sanitization of the environment. The human exposure limits were calculated following the guidelines provided by the International Commission on Non-Ionizing Radiation Protection and the International Commission on Illumination. Antibacterial activity was evaluated on , and . The maximum human exposure duration has been identified at different irradiation distance and angle, increasing with the increase of both parameters. Bactericidal activity was observed in all microorganisms and was higher with higher exposure time and at lower distance from the source. Noteworthily, in equal conditions of radiant exposure, the exposure time impacts on the bactericidal activity more than the distance from the source. The modulation of factors such as distance from the source, exposure time and irradiation angle can enable effective antibacterial activity and human safety. Prolonged direct irradiation of the surfaces associated with indirect human exposure represents the condition of greater efficacy and safety.
紫外线辐射被用于消毒，但对人体有不良的健康影响。与 UV-B 和 UV-C 相比，UV-A 辐射的杀菌效果较低，但健康风险较低，因此有可能在有人存在的情况下，在控制暴露条件下对环境进行消毒。我们通过确定在安全暴露条件下使用 UV-A 灯并有效地对环境进行消毒来研究这种可能性。人类暴露限值是根据国际非电离辐射防护委员会和国际照明委员会提供的指南计算的。评估了 、 和 的抗菌活性。最大的人类暴露持续时间在不同的照射距离和角度下被确定，随着这两个参数的增加而增加。在所有微生物中都观察到杀菌活性，并且随着暴露时间的增加和与源的距离的降低而更高。值得注意的是，在相同的辐射暴露条件下，暴露时间对杀菌活性的影响大于与源的距离。通过调节距离、暴露时间和照射角度等因素，可以实现有效的抗菌活性和人体安全性。长时间直接照射与间接人体暴露相关的表面代表了更有效和安全的条件。
