铜可抑制对去甲肾上腺素的升压反应，但对钾无此作用。与前列腺素E1、E2和I2以及青霉胺的相互作用。

Copper inhibits pressor responses to noradrenaline but not potassium. Interactions with prostaglandins E1, E2, and I2 and penicillamine.

作者信息

Cunnane S C, Zinner H, Horrobin D F, Manku M S, Morgan R O, Karmali R A, Ally A I, Karmazyn M, Barnette W E, Nicolaou K C

出版信息

Can J Physiol Pharmacol. 1979 Jan;57(1):35-40. doi: 10.1139/y79-005.

DOI:10.1139/y79-005

PMID:371766

Abstract

Low concentrations of copper inhibited responses to norepinephrine and angiotensin (IC50 3 X 10(-6) M) but not to potassium in rat mesenteric vascular preparations perfused either with buffer or indomethacin and prostaglandin (PGE2). The dose-response curve was not shifted by indomethacin, imidazole, or PGE2 but was moved to the right by 2.8 X 10(-11) M PGE1 and to the left by 2.8 X 10(-7) M PGE1. These effects of copper are similar to the effects of PGI2 in the preparation. Copper moved the PGI2 dose-response curve against noradrenaline in parallel to the left, suggesting that the two were interacting at some point. Penicillamine, which may stimulate PGE1 synthesis, had PGE1-like interactions with the copper effect, suggesting that its value in Wilson's disease may be partly due to antagonism of the biological action of copper as well as to its copper-chelating properties.

摘要

低浓度铜可抑制大鼠肠系膜血管制剂对去甲肾上腺素和血管紧张素的反应（IC50为3×10⁻⁶ M），但在用缓冲液或吲哚美辛与前列腺素（PGE₂）灌注时，对钾的反应无抑制作用。吲哚美辛、咪唑或PGE₂不会使剂量反应曲线发生位移，但2.8×10⁻¹¹ M的PGE₁会使曲线右移，而2.8×10⁻⁷ M的PGE₁会使曲线左移。铜的这些作用与该制剂中前列环素（PGI₂）的作用相似。铜使PGI₂对去甲肾上腺素的剂量反应曲线平行左移，表明二者在某一点上相互作用。可能刺激PGE₁合成的青霉胺与铜的作用具有类似PGE₁的相互作用，这表明其在威尔逊病中的价值可能部分归因于对铜生物作用的拮抗以及其铜螯合特性。