Research Service, Veterans Administration Medical Center, 91343, Sepulveda, CA, USA.
Biol Trace Elem Res. 1986 Dec;11(1):75-88. doi: 10.1007/BF02795526.
Effects of altered dietary zinc on levels of zinc, copper, magnesium, and calcium in organ and peripheral tissues were studied. When rats fed a zinc-deficient diet (1.3 μg Zn/g) for 28 d were compared with rats fed a control diet (37.5 μg Zn/g), levels of zinc were slightly lower in plasma, hair, and skin and 50% lower in femur and pancreas, whereas the levels of copper were higher in all tissue except plasma. Magnesium levels were higher than controls in the heart and lower in the spleen, whereas the calcium levels were lower in plasma, lung, spleen, kidney, and skin and strikingly higher in brain, hair, and femur. When rats fed a zinc-supplemented diet (1.0 mg Zn/g) were compared to the same conrols, levels of zinc in these were higher in all organs and peripheral tissues studied, except heart, lung, and liver; copper levels were higher in liver, kidney, and spleen; magnesium levels were significantly higher in the spleen, but were little affected in other tissues, although calcium levels were higher in pancreas, spleen, kidney, and skin and lower in plasma and hair. These data indicate that overall copper organ and peripheral tissue levels are affected inversely, and zinc and calcium levels directly, by zinc nutriture.
研究了膳食锌改变对器官和外周组织中锌、铜、镁和钙水平的影响。当给喂食缺锌饮食（1.3μg Zn/g）28 天的大鼠与喂食对照饮食（37.5μg Zn/g）的大鼠进行比较时，发现除了血浆，锌在血浆、毛发和皮肤中的水平略低，在股骨和胰腺中的水平低 50%，而铜在除了血浆以外的所有组织中的水平都更高。镁的水平在心脏中高于对照，在脾脏中较低，而钙的水平在血浆、肺、脾脏、肾脏和皮肤中较低，在大脑、毛发和股骨中则明显较高。当给喂食补锌饮食（1.0mg Zn/g）的大鼠与相同的对照进行比较时，除了心脏、肺和肝脏，锌在所有研究的器官和外周组织中的水平都更高；铜的水平在肝脏、肾脏和脾脏中更高；镁的水平在脾脏中显著升高，但在其他组织中几乎没有受到影响，尽管钙的水平在胰腺、脾脏、肾脏和皮肤中较高，在血浆和毛发中较低。这些数据表明，总体而言，铜的器官和外周组织水平与锌的营养状况呈负相关，而锌和钙水平与锌的营养状况呈正相关。
