Culié Dorian, Schiappa Renaud, Pace-Loscos Tanguy, Guelfucci Bruno, Vergez Sebastien, Garrel Renaud, Fakhry Nicolas, Dassonville Olivier, Poissonnet Gilles, Lallemant Benjamin, Sudaka Anne, Saada-Bouzid Esma, Benezery Karen, Temam Stephane, Gorphe Phillipe, Chamorey Emmanuel, Bozec Alexandre
Antoine Lacassagne Centre, University Institute of the Face and Neck, Côte d'Azur University, 06000 Nice, France.
Antoine Lacassagne Centre, Department of Epidemiology, Biostatistics and Health Data, Côte d'Azur University, 06000 Nice, France.
J Clin Med. 2023 Apr 28;12(9):3169. doi: 10.3390/jcm12093169.
Nutritional support during radiotherapy is crucial to tolerating and completing oropharyngeal squamous cell carcinoma (OPSCC) treatment. The impact of HPV status on nutritional support is debated. The objective was to evaluate the rate of Reactive Feeding Tube (RFT) use and determine its prognostic factors during definitive radiotherapy for OPSCC. All OPSCC patients treated from 2009 to 2014 were included in this multicentric retrospective study. The impact of tumor p16 status on the risk of RFT was assessed through multivariate analyses. Among the 543 patients, 103 patients required an RFT (19.0%). The use of RFT differed between centers (5% to 32.4%). In multivariate analysis, only tongue base involvement and concurrent chemotherapy were significantly associated with RFT (OR = 2.18 and 3.7, respectively). Tongue base involvement and concomitant chemotherapy were prognostic factors for RFT. HPV status was not a prognostic factor for enteral nutrition during radiotherapy for OPSCC.
放疗期间的营养支持对于耐受并完成口咽鳞状细胞癌（OPSCC）治疗至关重要。人乳头瘤病毒（HPV）状态对营养支持的影响存在争议。本研究的目的是评估在OPSCC根治性放疗期间反应性饲管（RFT）的使用比例，并确定其预后因素。2009年至2014年接受治疗的所有OPSCC患者均纳入这项多中心回顾性研究。通过多因素分析评估肿瘤p16状态对RFT风险的影响。在543例患者中，103例患者需要使用RFT（19.0%）。各中心之间RFT的使用情况有所不同（5%至32.4%）。在多因素分析中，仅舌根受累和同步化疗与RFT显著相关（OR分别为2.18和3.7）。舌根受累和同步化疗是RFT的预后因素。HPV状态不是OPSCC放疗期间肠内营养的预后因素。
