Snyder J R, Pascoe J R, Hietala S K, Holland M, Baggot D J
Am J Vet Res. 1986 May;47(5):1092-5.
Gentamicin sulfate (2.2 mg/kg of body weight, IV) was given to anesthetized horses. Jejunal and large colon tissue samples (1 g), serum, and urine were collected over a 4-hour period. Maximum gentamicin concentrations in serum (10.06 +/- 2.85 micrograms/ml) occurred at 0.25 hours after injection. Maximum gentamicin concentrations in the large colon (4.13 +/- 1.80 micrograms/ml) and jejunum (2.26 +/- 1.35 micrograms/ml) occurred in horses at 0.5 and 0.33 hours, respectively. Tissue concentrations decreased in parallel with serum concentrations and were still detectable at the end of the 4-hour period. During the time that samples were collected, the total amount of gentamicin excreted in the urine ranged from 7.21 +/- 3.11 mg to 11.91 +/- 7.12 mg, with a mean urinary concentration of 57.01 +/- 5.37 micrograms/ml. Over the 4-hour collection period, the fraction of dose that was excreted unchanged in the urine was 4.8 +/- 1.9%. Pharmacokinetic analyses of the serum concentration-time data gave a serum half-life of 2.52 +/- 1.29 hours, volume of distribution of 227 +/- 83 ml/kg, and body clearance of 1.12 +/- 0.26 ml/min/kg. The half-lives of the antibiotic in the jejunum and large colon were 1.32 and 1.33 hours, respectively.
给麻醉后的马静脉注射硫酸庆大霉素（2.2毫克/千克体重）。在4小时内收集空肠和大结肠组织样本（1克）、血清和尿液。血清中庆大霉素的最大浓度（10.06±2.85微克/毫升）在注射后0.25小时出现。大结肠（4.13±1.80微克/毫升）和空肠（2.26±1.35微克/毫升）中庆大霉素的最大浓度分别在0.5小时和0.33小时出现在马体内。组织浓度与血清浓度平行下降，在4小时结束时仍可检测到。在收集样本期间，尿中排出的庆大霉素总量为7.21±3.11毫克至11.91±7.12毫克，平均尿浓度为57.01±5.37微克/毫升。在4小时的收集期内，尿中以原形排出的剂量分数为4.8±1.9%。血清浓度-时间数据的药代动力学分析得出血清半衰期为2.52±1.29小时，分布容积为227±83毫升/千克，机体清除率为1.12±0.26毫升/分钟/千克。抗生素在空肠和大结肠中的半衰期分别为1.32小时和1.33小时。
