Bruni J
Can Med Assoc J. 1979 Apr 7;120(7):817-24.
Recent advances in drug therapy for epilepsy have contributed to the reduction in the proportion of persons whose epilepsy is uncontrolled. New knowledge of the pharmacokinetics of phenytoin has led to a better understanding of the drug's bioavailability and uses. Carbamazepine has recently been introduced for the treatment of generalized tonic-clonic and partial seizures. Clonazepam has been found of particular benefit in the treatment of absence and myoclonic seizures. Valproic acid is a promising antiepileptic drug with broad-spectrum activity, and is particularly useful in the treatment of absence and myoclonic seizures, although further clinical experience is required before it can supplant ethosuximide as the preferred drug for the treatment of absence seizures. Monitoring of the plasma concentration of antiepileptic drugs has added greatly to the achievement of optimal drug therapy and the prevention of toxic effects.
癫痫药物治疗的最新进展有助于降低癫痫未得到控制的人群比例。苯妥英钠药代动力学的新知识使人们对该药物的生物利用度和用途有了更好的理解。卡马西平最近已被用于治疗全身性强直阵挛发作和部分性发作。氯硝西泮已被发现对失神发作和肌阵挛发作的治疗特别有益。丙戊酸是一种有前景的抗癫痫药物，具有广谱活性，在失神发作和肌阵挛发作的治疗中特别有用，不过在它能够取代乙琥胺成为失神发作治疗的首选药物之前，还需要更多的临床经验。监测抗癫痫药物的血浆浓度对实现最佳药物治疗和预防毒性作用有很大帮助。
