Deisenhammer E, Sommer R, Nitsche V
Wien Klin Wochenschr. 1980 Jan 4;92(1):23-4.
19 patients were treated with valproic acid (VPR) in combination with classical anticonvulsants (phenytoin, phenobarbitone, primidone, carbamazepine). Patients with a mean serum concentration of 340 micron moles/l showed a marked improvement as to the frequency of seizures or were even completely free from seizures, provided that the other anticonvulsants were also given in the therapeutic range. Cases showing only a slight reduction in seizure frequency or no improvement had a mean serum level of 229 micron moles/l. This investigation shows that in severe cases of epilepsy treated by combined therapy all given anticonvulsants must reach therapeutic levels to achieve effective control of seizures in most patients.
19名患者接受了丙戊酸（VPR）与传统抗惊厥药（苯妥英、苯巴比妥、扑米酮、卡马西平）联合治疗。平均血清浓度为340微摩尔/升的患者在癫痫发作频率方面有显著改善，或者甚至完全没有癫痫发作，前提是其他抗惊厥药也给予治疗范围内的剂量。癫痫发作频率仅略有降低或无改善的病例，其平均血清水平为229微摩尔/升。这项研究表明，在联合治疗的严重癫痫病例中，所有给予的抗惊厥药都必须达到治疗水平，才能在大多数患者中有效控制癫痫发作。
