Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
J Asian Nat Prod Res. 2023 Dec;25(12):1184-1190. doi: 10.1080/10286020.2023.2211550. Epub 2023 May 13.
Two new pregnane glycosides ( and ), together with four known ones (- ), were isolated from the roots of Royle ex Wight (Asclepiadaceae). On the basis of detailed spectroscopic analysis and chemical method, the structures of new compounds were characterized to be metaplexigenin 3---D-cymaropyranosyl- (1→4)--L-diginopyranosyl-(1→4)--D-cymaropyranoside (), metaplexigenin 3---L-diginopyranosyl-(1→4)--D-cymaropyranoside (). All the isolated compounds (-) were tested for their inhibitory activity against the growth of human colon cancer cell lines HCT-116. Compounds and showed significant cytoxicities with IC values of 43.58 µM and 52.21 µM.
从 Royle ex Wight（萝藦科）的根部分离得到两种新的孕烷糖苷（和），以及四种已知的化合物（-）。基于详细的光谱分析和化学方法，鉴定了新化合物的结构为 metaplexigenin 3---D-cymaropyranosyl-（1→4）--L-diginopyranosyl-（1→4）--D-cymaropyranoside（），metaplexigenin 3---L-diginopyranosyl-（1→4）--D-cymaropyranoside（）。所有分离得到的化合物（-）都被测试了对人结肠癌细胞系 HCT-116 的生长抑制活性。化合物和表现出显著的细胞毒性，IC 值分别为 43.58 μM 和 52.21 μM。
