从青羊参根中分离出的两种新的14,15-断孕甾烷型甾体糖苷。
Two new 14, 15-secopregnane-type steroidal glycosides from the roots of Cynanchum limprichtii.
作者信息
Liu Jia-Chuan, Yu Li-Li, Chen Shao-Fei, Lu Xiao-Jie, Zhao Dan, Wang Hai-Feng, Chen Gang, Pei Yue-Hu
机构信息
a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.
b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang , China.
出版信息
Nat Prod Res. 2018 Feb;32(3):261-267. doi: 10.1080/14786419.2017.1353506. Epub 2017 Jul 16.
Two new steroidal glycosides 1 and 2, along with three known ones (3-5), were isolated from the 95% ethanol extract of the roots of Cynanchum limprichtii Schltr. The structure of the new compounds was elucidated as 3-O-α-L-diginopyranosyl-(1→4)-β-D-digitoxopyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-thevetopyranosyl-14, 16:15, 20:18, 20-triepoxy-14, 15-secopregn-4, 6, 8 (14)-triene (1) and 3-O-α-L-cymaropyranosyl-(1→4)-β-D-digitoxopyranosyl- (1→4)-β-D-3-demethyl-2-deoxythevetopyranosyl-14, 16: 15, 20: 8, 20-triepoxy-14, 15-secopregn-5, 8 (14)-diene (2) on the basis of spectroscopic analysis together with acidic hydrolysis. All compounds showed cytotoxic activity against the human cancer cell line HL60, with IC values of 55.36, 65.41, 17.88, 17.68 and 33.5 μM, respectively. While, only compound 3 showed cytotoxicity against the Caco-2 cell line, with an IC value of 67.47 μM.
从青羊参（Cynanchum limprichtii Schltr.）根的95%乙醇提取物中分离得到两个新的甾体糖苷1和2，以及三个已知化合物（3 - 5）。通过光谱分析和酸性水解确定了新化合物的结构分别为3 - O-α-L-洋地黄糖基-(1→4)-β-D-地高辛糖基-(1→4)-β-D-磁麻糖基-(1→4)-β-D-黄花夹竹桃糖基-14, 16:15, 20:18, 20-三环氧-14, 15-断孕甾-4, 6, 8(14)-三烯（1）和3 - O-α-L-磁麻糖基-(1→4)-β-D-地高辛糖基-(1→4)-β-D-3-去甲基-2-脱氧黄花夹竹桃糖基-14, 16:15, 20:8, 20-三环氧-14, 15-断孕甾-5, 8(14)-二烯（2）。所有化合物对人癌细胞系HL60均表现出细胞毒性活性，IC值分别为55.36、65.41、17.88、17.68和33.5 μM。同时，只有化合物3对Caco-2细胞系表现出细胞毒性，IC值为67.47 μM。
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