Department of Psychology, University of Kentucky, USA.
Department of Psychology, University of Kentucky, USA.
Drug Alcohol Depend. 2023 Jul 1;248:109899. doi: 10.1016/j.drugalcdep.2023.109899. Epub 2023 Apr 26.
Acute alcohol responses such as tolerance to alcohol-induced motor impairment and heightened sensitivity to alcohol-induced disinhibition are associated with heavier drinking. Additionally, certain cognitive characteristics may also indicate problem-drinking. For example, cognitive and emotional preoccupation (CEP) with alcohol is associated with heavier drinking. However, it is not clear if cognitive markers have value as predicators of heavier drinking beyond that of well-established alcohol response markers. The current study sought to test the predictive potential of CEP in the context of two well-documented alcohol response markers of heavy drinking.
Data aggregated from three studies comprised a sample of 94 young adult drinkers with no history of alcohol use disorder. Participants' motor coordination (grooved pegboard) and behavioral disinhibition (cued go/no-go) were assessed following consumption of 0.65g/kg alcohol and a placebo. CEP was measured via the Temptation and Restraint Inventory (TRI).
Drinkers who expressed both alcohol response markers reported drinking higher doses regardless of their level of CEP. Among drinkers who expressed low sensitivity to both disinhibition and motor impairment, higher CEP was associated with higher typical quantities. Low sensitivity to motor impairment functioned as a standalone marker of heavier drinking.
The findings suggest that a combination of tolerance to motor impairment and high alcohol-induced disinhibition may be sufficient to promote heavier consumption even in the absence of cognitive markers associated with problem drinking. Results also suggest that cognitive characteristics may drive early drinking and contribute to the development of tolerance to acute alcohol effects.
急性酒精反应，如对酒精引起的运动障碍的耐受性和对酒精引起的抑制作用的敏感性增加，与饮酒量增加有关。此外，某些认知特征也可能表明存在问题饮酒。例如，对酒精的认知和情绪困扰（CEP）与饮酒量增加有关。然而，目前尚不清楚认知标志物是否除了已经确立的酒精反应标志物之外，还有预测更大量饮酒的价值。本研究旨在测试 CEP 在两个有充分文献记载的大量饮酒的酒精反应标志物背景下的预测潜力。
从三项研究中汇总的数据构成了一个没有酒精使用障碍史的 94 名年轻成年饮酒者样本。参与者在摄入 0.65g/kg 酒精和安慰剂后，评估其运动协调能力（凹槽钉板）和行为抑制作用（线索 Go/No-Go）。通过 Temptation and Restraint Inventory (TRI) 测量 CEP。
表达两种酒精反应标志物的饮酒者报告说，无论他们的 CEP 水平如何，他们的饮酒量都更高。在对抑制作用和运动障碍都低敏感的饮酒者中，较高的 CEP 与较高的典型饮酒量相关。对运动障碍的低敏感性是更大量饮酒的独立标志物。
研究结果表明，对运动障碍的耐受性和高酒精引起的抑制作用的结合可能足以促进更大量的饮酒，即使在没有与问题饮酒相关的认知标志物的情况下也是如此。结果还表明，认知特征可能会推动早期饮酒，并有助于对急性酒精效应的耐受性的发展。
