Kotila M
Ann Clin Res. 1986;18(2):76-9.
A 4-year follow-up study was carried out on the prognosis of 54 patients (36 men and 18 women) who survived their first ischaemic brain infarction which had occurred under the age of 65. Twenty patients (15 men and 5 women) already had documented atherosclerotic vascular disease other than ischaemic brain infarction at the time of the hospital admission (atherosclerotic group). When both sexes were considered together, mortality during the 4-year follow-up was significantly higher in the atherosclerotic group than in the non-atherosclerotic group (6/20 versus 3/34; p less than 0.05) and this was due to an excess of cerebrovascular mortality (4/20 versus 0/34; p less than 0.05). The incidence of recurrent fatal or non-fatal ischaemic brain infarction was significantly higher in the atherosclerotic group than in the non-atherosclerotic group (8/20 versus 3/34; p less than 0.01). Among those patients who survived the 4-year follow-up period the incidence of new non-fatal atherosclerotic vascular events (cerebrovascular accident, myocardial infarction, other heart disease or intermittent claudication) was significantly higher in the atherosclerotic group than in the non-atherosclerotic group (8/14 versus 8/31; p less than 0.05). It is concluded, that the presence of atherosclerotic vascular disease at the time of first ischaemic brain infarction in patients under the age of 65 is associated with a significantly increased risk for recurrent ischaemic brain infarction or other new atherosclerotic vascular events.
对54例（36例男性和18例女性）首次缺血性脑梗死发生于65岁以下且存活下来的患者进行了一项为期4年的预后研究。20例患者（15例男性和5例女性）在入院时已有除缺血性脑梗死之外的动脉粥样硬化性血管疾病记录（动脉粥样硬化组）。当将男女两性合并考虑时，动脉粥样硬化组4年随访期间的死亡率显著高于非动脉粥样硬化组（6/20对3/34；p<0.05），这是由于脑血管死亡率过高（4/20对0/34；p<0.05）。动脉粥样硬化组复发性致命或非致命性缺血性脑梗死的发生率显著高于非动脉粥样硬化组（8/20对3/34；p<0.01）。在那些存活至4年随访期的患者中，动脉粥样硬化组新的非致命性动脉粥样硬化性血管事件（脑血管意外、心肌梗死、其他心脏病或间歇性跛行）的发生率显著高于非动脉粥样硬化组（8/14对8/31；p<0.05）。得出结论，65岁以下患者首次缺血性脑梗死时存在动脉粥样硬化性血管疾病与复发性缺血性脑梗死或其他新的动脉粥样硬化性血管事件的风险显著增加相关。
