Wu Shanshan, Fan Jiali, Tang Fajuan, Chen Lin, Zhang Xiaoyan, Xiao Dongqiong, Li Xihong
Emergency Department, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
Front Neurosci. 2023 Apr 26;17:1123561. doi: 10.3389/fnins.2023.1123561. eCollection 2023.
There are many special sites at the end of a synapse called active zones (AZs). Synaptic vesicles (SVs) fuse with presynaptic membranes at these sites, and this fusion is an important step in neurotransmitter release. The cytomatrix in the active zone (CAZ) is made up of proteins such as the regulating synaptic membrane exocytosis protein (RIM), RIM-binding proteins (RIM-BPs), ELKS/CAST, Bassoon/Piccolo, Liprin-α, and Munc13-1. RIM is a scaffold protein that interacts with CAZ proteins and presynaptic functional components to affect the docking, priming, and fusion of SVs. RIM is believed to play an important role in regulating the release of neurotransmitters (NTs). In addition, abnormal expression of RIM has been detected in many diseases, such as retinal diseases, Asperger's syndrome (AS), and degenerative scoliosis. Therefore, we believe that studying the molecular structure of RIM and its role in neurotransmitter release will help to clarify the molecular mechanism of neurotransmitter release and identify targets for the diagnosis and treatment of the aforementioned diseases.
在突触末端有许多特殊位点，称为活性区（AZs）。突触小泡（SVs）在这些位点与突触前膜融合，而这种融合是神经递质释放的重要步骤。活性区细胞基质（CAZ）由诸如调节突触膜胞吐作用蛋白（RIM）、RIM结合蛋白（RIM - BPs）、ELKS/CAST、巴松管/短笛蛋白、Liprin - α和Munc13 - 1等蛋白质组成。RIM是一种支架蛋白，它与CAZ蛋白和突触前功能成分相互作用，以影响突触小泡的对接、启动和融合。RIM被认为在调节神经递质（NTs）释放中起重要作用。此外，在许多疾病中已检测到RIM的异常表达，如视网膜疾病、阿斯伯格综合征（AS）和退行性脊柱侧凸。因此，我们认为研究RIM的分子结构及其在神经递质释放中的作用将有助于阐明神经递质释放的分子机制，并确定上述疾病的诊断和治疗靶点。
