Wei Zidong, Chen Qiaoyan, Han Shihong, Zhang Shuheng, Zhang Na, Zhang Lei, Wang Haining, He Qiang, Cao Peng, Zhang Xiaoliang, Liang Dong, Liu Xin, Li Ye, Zheng Hairong
Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
The Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China.
Quant Imaging Med Surg. 2023 May 1;13(5):3222-3240. doi: 10.21037/qims-22-945. Epub 2023 Mar 29.
BACKGROUND: We aimed to demonstrate the feasibility of generating high-resolution human brain magnetic resonance imaging (MRI) at 5 Tesla (T) using a quadrature birdcage transmit/48-channel receiver coil assembly. METHODS: A quadrature birdcage transmit/48-channel receiver coil assembly was designed for human brain imaging at 5T. The radio frequency (RF) coil assembly was validated by electromagnetic (EM) simulations and phantom imaging experimental studies. The simulated B1+ field inside a human head phantom and inside a human head model generated by the birdcage coils driven in circularly polarized (CP) mode at 3T, 5T and 7T was compared. Signal-to-noise ratio (SNR) maps, the inverse g-factor maps for evaluation of parallel imaging performance, anatomic images, angiography images, vessel wall images and susceptibility weighted images (SWI) were acquired using the RF coil assembly at 5T and compared to those acquired using a 32-channel head coil on a 3T MRI scanner. RESULTS: For the EM simulations, 5T MRI provided less RF inhomogeneity compared to that of 7T. In the phantom imaging study, the distributions of the measured B1+ field were consistent with the distributions of the simulated B1+ field. In the human brain imaging study, the average SNR value of the brain in the transversal plane at 5T was 1.6 times of that at 3T. The 48-channel head coil at 5T had higher parallel acceleration capability than the 32-channel head coil at 3T. The anatomic images at 5T also showed higher SNR than those at 3T. Improved delineation of the hippocampus, lenticulostriate arteries, and basilar arteries was observed at 5T compared to 3T. SWI with a higher resolution of 0.3 mm ×0.3 mm ×1.2 mm could be acquired at 5T, which enabled better visualization of small blood vessels compared to that at 3T. CONCLUSIONS: 5T MRI can provide significant SNR improvement compared to that of 3T with less RF inhomogeneity than that of 7T. The ability to obtain high quality in vivo human brain images at 5T using the quadrature birdcage transmit/48-channel receiver coil assembly has significant in clinical and scientific research applications.
背景：我们旨在证明使用正交鸟笼式发射/48通道接收线圈组件在5特斯拉（T）下生成高分辨率人脑磁共振成像（MRI）的可行性。 方法：设计了一种用于5T人脑成像的正交鸟笼式发射/48通道接收线圈组件。通过电磁（EM）模拟和体模成像实验研究对射频（RF）线圈组件进行了验证。比较了在3T、5T和7T下由鸟笼线圈以圆极化（CP）模式驱动时，在人体头部体模和人体头部模型内模拟的B1+场。使用5T的RF线圈组件获取信噪比（SNR）图、用于评估并行成像性能的逆g因子图、解剖图像、血管造影图像、血管壁图像和磁敏感加权图像（SWI），并与在3T MRI扫描仪上使用32通道头部线圈获取的图像进行比较。 结果：对于EM模拟，与7T相比，5T MRI的RF不均匀性更小。在体模成像研究中，测量的B1+场分布与模拟的B1+场分布一致。在人脑成像研究中，5T时大脑横断面的平均SNR值是3T时的1.6倍。5T的48通道头部线圈比3T的32通道头部线圈具有更高的并行加速能力。5T时的解剖图像也显示出比3T时更高的SNR。与3T相比，在5T时观察到海马体、豆纹动脉和基底动脉的描绘得到改善。在5T时可以获取分辨率更高的0.3 mm×0.3 mm×1.2 mm的SWI，与3T相比，能够更好地显示小血管。 结论：与3T相比，5T MRI可以显著提高SNR，且RF不均匀性比7T小。使用正交鸟笼式发射/48通道接收线圈组件在5T下获得高质量体内人脑图像的能力在临床和科研应用中具有重要意义。
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